{"id":11573,"date":"2025-11-11T01:12:28","date_gmt":"2025-11-11T00:12:28","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/les-scientifiques-revelent-une-autre-piece-du-long-puzzle-du-covid\/"},"modified":"2025-11-11T01:12:31","modified_gmt":"2025-11-11T00:12:31","slug":"les-scientifiques-revelent-une-autre-piece-du-long-puzzle-du-covid","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/les-scientifiques-revelent-une-autre-piece-du-long-puzzle-du-covid\/","title":{"rendered":"Les scientifiques r\u00e9v\u00e8lent une autre pi\u00e8ce du long puzzle du COVID"},"content":{"rendered":"
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Chez les patients atteints de COVID long, une nouvelle \u00e9tude a r\u00e9v\u00e9l\u00e9 une association structurelle entre les microcaillots circulants et les pi\u00e8ges extracellulaires \u00e0 neutrophiles (TNE).<\/p>\n

Cette d\u00e9couverte sugg\u00e8re l\u2019existence d\u2019interactions physiologiques sous-jacentes entre les microcaillots et les NETS qui, lorsqu\u2019elles sont d\u00e9r\u00e9gul\u00e9es, peuvent devenir pathog\u00e8nes. L’ouvrage est publi\u00e9 dans le Journal de virologie m\u00e9dicale<\/i>.<\/p>\n

Que sont les microcaillots ?<\/h2>\n

Le terme microcaillots, r\u00e9cemment adopt\u00e9 dans la litt\u00e9rature scientifique, d\u00e9signe des amas anormaux de prot\u00e9ines de la coagulation sanguine circulant dans la circulation sanguine d’un patient. Le concept a \u00e9t\u00e9 introduit en 2021 par le professeur Resia Pretorius du d\u00e9partement des sciences physiologiques de l’universit\u00e9 de Stellenbosch, lorsqu’ils ont d\u00e9couvert la pr\u00e9sence anormale de tels microcaillots dans les \u00e9chantillons de sang de patients atteints de COVID-19. Cette d\u00e9couverte a suscit\u00e9 une large attention pendant la pand\u00e9mie en raison de son r\u00f4le potentiel dans les coagulopathies li\u00e9es au COVID.<\/p>\n

Que sont les pi\u00e8ges extracellulaires \u00e0 neutrophiles (TNE)\u00a0?<\/h2>\n

L’\u00e9quipe du Dr Alain Thierry de l’Institut du Cancer de Montpellier (IRCM) de l’INSERM \u00e0 Montpellier, a \u00e9t\u00e9 parmi les premi\u00e8res \u00e0 identifier le r\u00f4le critique des TNE dans la pathogen\u00e8se du COVID-19. Les NET sont produites par une forme sp\u00e9cialis\u00e9e de r\u00e9ponse immunitaire inn\u00e9e connue sous le nom de NETosis, dans laquelle les neutrophiles expulsent leur ADN pour former des structures filamenteuses int\u00e9gr\u00e9es \u00e0 des enzymes cytotoxiques capables de pi\u00e9ger et de neutraliser rapidement les agents pathog\u00e8nes.<\/p>\n

Cependant, la formation excessive de TNE peut devenir n\u00e9faste, contribuant \u00e0 un large \u00e9ventail de maladies inflammatoires et thrombotiques, notamment des infections graves, des maladies auto-immunes, le cancer, le diab\u00e8te et l’arthrite.<\/p>\n

Selon le Dr Thierry, il se pourrait que la surproduction persistante de TNE, aliment\u00e9e par des boucles inflammatoires et thrombotiques auto-entretenues, exacerbe la gravit\u00e9 de la maladie.<\/p>\n

Dans le cadre d\u2019un effort collaboratif, les \u00e9quipes du Pr Pretorius et du Dr Thierry ont \u00e9tudi\u00e9 l\u2019interaction potentielle entre les microcaillots et les TNE dans le contexte d\u2019un long COVID.<\/p>\n

Principales conclusions<\/h2>\n

En utilisant la cytom\u00e9trie en flux d\u2019imagerie et la microscopie \u00e0 fluorescence, ils ont effectu\u00e9 une analyse quantitative et structurelle des microcaillots et des TNE dans le plasma de patients atteints de COVID long, par rapport \u00e0 des t\u00e9moins sains. Les NET ont \u00e9galement \u00e9t\u00e9 quantifi\u00e9s en analysant les marqueurs prot\u00e9iques des NET et l’ADN en circulation.<\/p>\n

    \n
  • Ils ont observ\u00e9 une augmentation significative des biomarqueurs associ\u00e9s aux microcaillots et aux TNE dans les \u00e9chantillons de patients.<\/li>\n
  • Les microcaillots \u00e9taient non seulement plus abondants, mais \u00e9galement plus gros chez les patients.<\/li>\n
  • Plus important encore, ils ont d\u00e9couvert une association structurelle non signal\u00e9e auparavant entre les microcaillots et les TNE, observ\u00e9e chez tous les sujets mais nettement plus prononc\u00e9e chez les patients atteints de COVID longue.<\/li>\n<\/ul>\n

    \u00ab\u00a0Cette d\u00e9couverte sugg\u00e8re l’existence d’interactions physiologiques sous-jacentes entre les microcaillots et les TNE qui, lorsqu’elles sont d\u00e9r\u00e9gul\u00e9es, peuvent devenir pathog\u00e8nes\u00a0\u00bb, explique le Dr Thierry.<\/p>\n

    De plus, l\u2019int\u00e9gration d\u2019outils d\u2019intelligence artificielle, tels que l\u2019apprentissage automatique, dans l\u2019analyse des biomarqueurs leur a permis de distinguer avec une grande pr\u00e9cision les patients atteints d\u2019une longue COVID des individus en bonne sant\u00e9. Les algorithmes ont identifi\u00e9 les combinaisons de biomarqueurs les plus pr\u00e9dictives, am\u00e9liorant ainsi la fiabilit\u00e9 du diagnostic et ouvrant la voie \u00e0 des approches de m\u00e9decine personnalis\u00e9e.<\/p>\n

    Selon le professeur Pretorius, les r\u00e9sultats r\u00e9v\u00e8lent une accumulation significative de microcaillots dans le plasma des patients atteints de COVID longue, probablement entra\u00een\u00e9e et stabilis\u00e9e par une production excessive de TNE : \u00ab Cette interaction pourrait rendre les microcaillots plus r\u00e9sistants \u00e0 la fibrinolyse, favorisant leur persistance dans la circulation et contribuant aux complications microvasculaires chroniques \u00bb, explique-t-elle.<\/p>\n

    En identifiant le r\u00f4le m\u00e9caniste des TNE dans la stabilisation des microcaillots, cette \u00e9tude fournit de nouvelles informations sur la physiopathologie du COVID long. Ces r\u00e9sultats soutiennent le d\u00e9veloppement de strat\u00e9gies th\u00e9rapeutiques cibl\u00e9es visant \u00e0 moduler les r\u00e9ponses thrombo-inflammatoires.<\/p>\n

    Enfin, l’\u00e9tude ouvre la voie au d\u00e9veloppement de nouveaux biomarqueurs pour le diagnostic et la gestion : \u00ab La combinaison de techniques d’imagerie avanc\u00e9es et d’apprentissage automatique conf\u00e8re une robustesse m\u00e9thodologique et contribue de mani\u00e8re significative au discours scientifique en cours sur les syndromes post-viraux \u00bb, concluent-ils.<\/p>\n

    <\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

    Chez les patients atteints de COVID long, une nouvelle \u00e9tude a r\u00e9v\u00e9l\u00e9 une association structurelle<\/p>\n","protected":false},"author":1,"featured_media":11574,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[335,618,49,619,7617,2606,149,97,47],"class_list":["post-11573","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-autre","tag-covid","tag-les","tag-long","tag-piece","tag-puzzle","tag-revelent","tag-scientifiques","tag-une","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nLes scientifiques r\u00e9v\u00e8lent une autre pi\u00e8ce du long puzzle du COVID - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/les-scientifiques-revelent-une-autre-piece-du-long-puzzle-du-covid\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Les scientifiques r\u00e9v\u00e8lent une autre pi\u00e8ce du long puzzle du COVID - 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