{"id":11544,"date":"2025-11-10T15:42:04","date_gmt":"2025-11-10T14:42:04","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/une-enzyme-pourrait-etre-a-lorigine-de-la-dependance-a-lalcool-et-des-maladies-du-foie\/"},"modified":"2025-11-10T15:42:05","modified_gmt":"2025-11-10T14:42:05","slug":"une-enzyme-pourrait-etre-a-lorigine-de-la-dependance-a-lalcool-et-des-maladies-du-foie","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/une-enzyme-pourrait-etre-a-lorigine-de-la-dependance-a-lalcool-et-des-maladies-du-foie\/","title":{"rendered":"Une enzyme pourrait \u00eatre \u00e0 l\u2019origine de la d\u00e9pendance \u00e0 l\u2019alcool et des maladies du foie"},"content":{"rendered":"
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Les scientifiques ont d\u00e9couvert un lien surprenant entre le m\u00e9tabolisme du sucre et la d\u00e9pendance \u00e0 l\u2019alcool, identifiant une nouvelle cible th\u00e9rapeutique potentielle pour traiter les maladies h\u00e9patiques associ\u00e9es \u00e0 l\u2019alcool (ALD) et les troubles li\u00e9s \u00e0 la consommation d\u2019alcool (AUD).<\/p>\n

Dans une \u00e9tude parue dans M\u00e9tabolisme naturel<\/i>les chercheurs Anschutz de l’Universit\u00e9 du Colorado ont d\u00e9couvert que l’alcool d\u00e9clenche une voie m\u00e9tabolique dans le corps qui conduit \u00e0 la production interne de fructose, le m\u00eame type de sucre que l’on trouve couramment dans les aliments et les boissons sucr\u00e9s.<\/p>\n

Ce processus, pilot\u00e9 par l’enzyme k\u00e9tohexokinase (KHK), semble jouer un r\u00f4le cl\u00e9 dans le renforcement des habitudes de consommation d’alcool et dans l’acc\u00e9l\u00e9ration des l\u00e9sions h\u00e9patiques.<\/p>\n

Les chercheurs ont d\u00e9couvert que les souris d\u00e9pourvues de KHK pr\u00e9sentaient une inclination et une consommation d\u2019alcool nettement inf\u00e9rieures. Ces souris ont bu moins d\u2019alcool au cours de plusieurs tests, y compris des mod\u00e8les de consommation volontaire et bas\u00e9s sur la r\u00e9compense, et ont pr\u00e9sent\u00e9 une activit\u00e9 r\u00e9duite dans les r\u00e9gions du cerveau associ\u00e9es \u00e0 la d\u00e9pendance.<\/p>\n

Il est important de noter que les l\u00e9sions h\u00e9patiques induites par l’alcool semblaient inexistantes lorsque KHK \u00e9tait bloqu\u00e9, soit g\u00e9n\u00e9tiquement, soit par des m\u00e9dicaments. Les foies pr\u00e9sentaient une accumulation de graisse, une inflammation et des cicatrices r\u00e9duites, ce qui sugg\u00e8re qu’une interf\u00e9rence avec le m\u00e9tabolisme du fructose pourrait stopper, voire pr\u00e9venir, la progression des maladies h\u00e9patiques li\u00e9es \u00e0 l’alcool.<\/p>\n

\u00ab\u00a0Nos r\u00e9sultats montrent que l’alcool n’endommage pas seulement directement le foie, il d\u00e9tourne le m\u00e9tabolisme du sucre dans le corps d’une mani\u00e8re qui am\u00e9liore le comportement de consommation d’alcool et aggrave les l\u00e9sions h\u00e9patiques\u00a0\u00bb, a d\u00e9clar\u00e9 Miguel A. Lanaspa, DVM, Ph.D., professeur de recherche associ\u00e9 \u00e0 CU Anschutz et auteur principal.<\/p>\n

\u00ab\u00a0En ciblant le m\u00e9tabolisme du fructose, nous pourrons peut-\u00eatre briser ce cycle et d\u00e9velopper de nouveaux traitements contre la d\u00e9pendance \u00e0 l’alcool et les maladies du foie.\u00a0\u00bb<\/p>\n

\u00c9tant donn\u00e9 que les maladies h\u00e9patiques associ\u00e9es \u00e0 l’alcool et la maladie h\u00e9patique st\u00e9atosique associ\u00e9e \u00e0 un dysfonctionnement m\u00e9tabolique (MASLD) partagent des m\u00e9canismes pilot\u00e9s par le fructose, les r\u00e9sultats sugg\u00e8rent que les th\u00e9rapies con\u00e7ues pour inhiber le m\u00e9tabolisme du fructose pourraient b\u00e9n\u00e9ficier \u00e0 un large \u00e9ventail de patients atteints d’une maladie h\u00e9patique li\u00e9e \u00e0 l’alimentation ou \u00e0 la consommation d’alcool.<\/p>\n

\u00ab\u00a0Cette d\u00e9couverte met en \u00e9vidence une intersection inattendue entre le m\u00e9tabolisme du sucre et de l’alcool\u00a0\u00bb, a d\u00e9clar\u00e9 Richard Johnson, MD, professeur \u00e0 CU Anschutz et co-auteur de l’\u00e9tude. \u00ab\u00a0Cela ouvre des possibilit\u00e9s passionnantes pour d\u00e9velopper des traitements ciblant une voie commune sous-jacente aux maladies h\u00e9patiques m\u00e9taboliques et li\u00e9es \u00e0 l’alcool.\u00a0\u00bb<\/p>\n

La recherche ouvre une nouvelle direction prometteuse pour lutter contre les maladies du foie et la d\u00e9pendance \u00e0 l\u2019alcool, conditions pour lesquelles les traitements efficaces restent limit\u00e9s.<\/p>\n

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Les scientifiques ont d\u00e9couvert un lien surprenant entre le m\u00e9tabolisme du sucre et la d\u00e9pendance<\/p>\n","protected":false},"author":1,"featured_media":11545,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[35],"tags":[410,16,5728,204,191,6,1257,404,203,47],"class_list":["post-11544","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-addictions","tag-dependance","tag-des","tag-enzyme","tag-etre","tag-foie","tag-lalcool","tag-lorigine","tag-maladies","tag-pourrait","tag-une","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nUne enzyme pourrait \u00eatre \u00e0 l\u2019origine de la d\u00e9pendance \u00e0 l\u2019alcool et des maladies du foie - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/une-enzyme-pourrait-etre-a-lorigine-de-la-dependance-a-lalcool-et-des-maladies-du-foie\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Une enzyme pourrait \u00eatre \u00e0 l\u2019origine de la d\u00e9pendance \u00e0 l\u2019alcool et des maladies du foie - 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