{"id":11500,"date":"2025-11-08T00:02:39","date_gmt":"2025-11-07T23:02:39","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/une-etude-revele-les-consequences-de-la-maladie-glomerulaire-tout-au-long-de-la-vie\/"},"modified":"2025-11-08T00:02:41","modified_gmt":"2025-11-07T23:02:41","slug":"une-etude-revele-les-consequences-de-la-maladie-glomerulaire-tout-au-long-de-la-vie","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/une-etude-revele-les-consequences-de-la-maladie-glomerulaire-tout-au-long-de-la-vie\/","title":{"rendered":"Une \u00e9tude r\u00e9v\u00e8le les cons\u00e9quences de la maladie glom\u00e9rulaire tout au long de la vie"},"content":{"rendered":"
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De nouvelles recherches r\u00e9v\u00e8lent que contrairement aux id\u00e9es re\u00e7ues, les maladies glom\u00e9rulaires primaires ne sont pas n\u00e9cessairement b\u00e9nignes pour les enfants et les jeunes adultes. En fait, certains sous-groupes d\u2019enfants et de jeunes adultes peuvent conna\u00eetre un d\u00e9clin de la fonction r\u00e9nale plus rapide que les patients plus \u00e2g\u00e9s.<\/p>\n

Les r\u00e9sultats seront pr\u00e9sent\u00e9s lors de l\u2019ASN Kidney Week 2025 du 5 au 9 novembre.<\/p>\n

Les comparaisons directes des r\u00e9sultats entre les patients adultes et p\u00e9diatriques atteints de maladies glom\u00e9rulaires primaires sont rares, notamment la maladie \u00e0 changement minimal (MCD), la glom\u00e9ruloscl\u00e9rose segmentaire focale (FSGS), la n\u00e9phropathie membraneuse (MN) et la n\u00e9phropathie \u00e0 IgA (IgAN).<\/p>\n

Les chercheurs ont analys\u00e9 les donn\u00e9es de CureGN, l’une des plus grandes \u00e9tudes de cohorte longitudinales sur les maladies glom\u00e9rulaires. Lorsqu’ils ont examin\u00e9 le taux de d\u00e9clin de la fonction r\u00e9nale et le risque de progression vers le r\u00e9sultat composite d’une insuffisance r\u00e9nale, une baisse \u2265 40 % du d\u00e9bit de filtration glom\u00e9rulaire estim\u00e9 (DFGe) ou un d\u00e9c\u00e8s, les enfants et les jeunes adultes pr\u00e9sentaient des risques similaires, voire plus \u00e9lev\u00e9s, de rencontrer ces effets ind\u00e9sirables en tant qu’adultes plus \u00e2g\u00e9s.<\/p>\n

Les patients p\u00e9diatriques ayant re\u00e7u un diagnostic de MCD par biopsie pr\u00e9sentaient des baisses du DFGe plus prononc\u00e9es que les patients adultes atteints de MCD. Les patients MN \u00e2g\u00e9s de 13 \u00e0 17 ans et les patients atteints de n\u00e9phropathie FSGS et IgA \u00e2g\u00e9s de 18 \u00e0 44 ans au moment de la biopsie pr\u00e9sentaient les baisses les plus marqu\u00e9es du DFGe parmi leurs cohortes de diagnostic.<\/p>\n

Pour les patients atteints de MCD, FSGS et MN, aucune diff\u00e9rence n’a \u00e9t\u00e9 d\u00e9tect\u00e9e entre les diff\u00e9rents groupes d’\u00e2ge dans le risque de progression vers le r\u00e9sultat composite de d\u00e9c\u00e8s, d’insuffisance r\u00e9nale ou de diminution du DFGe \u2265 40 %, tandis que les patients atteints de n\u00e9phropathie \u00e0 IgA \u00e2g\u00e9s de 6 \u00e0 12 ans, 13 \u00e0 17 ans et 45 \u00e0 64 ans pr\u00e9sentaient des risques de progression plus faibles que ceux \u00e2g\u00e9s de 18 \u00e0 44 ans.<\/p>\n

\u00ab\u00a0Ces r\u00e9sultats sugg\u00e8rent que les jeunes patients qui obtiennent un diagnostic de maladie glom\u00e9rulaire primaire par biopsie r\u00e9nale courent un risque important d’atteindre une insuffisance r\u00e9nale et de n\u00e9cessiter une dialyse et\/ou une greffe au cours de leur vie. Nous pensons que de futures \u00e9tudes sont n\u00e9cessaires pour faire la lumi\u00e8re sur le fardeau et la morbidit\u00e9 des maladies glom\u00e9rulaires primaires chez les patients diagnostiqu\u00e9s \u00e0 un jeune \u00e2ge\u00a0\u00bb, a d\u00e9clar\u00e9 l’auteur principal Margaret Helmuth, MS, de l’Universit\u00e9 du Michigan, Ann Arbor.<\/p>\n

\u00ab\u00a0Notre recherche met \u00e9galement en \u00e9vidence l’importance d’inclure les enfants dans les essais cliniques sur le traitement de la maladie afin d’att\u00e9nuer les effets ind\u00e9sirables auxquels ils sont confront\u00e9s\u00a0\u00bb, a ajout\u00e9 le co-auteur Chia-shi Wang, MD, MSc, de l’\u00c9cole de m\u00e9decine de l’Universit\u00e9 Emory.<\/p>\n

<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

De nouvelles recherches r\u00e9v\u00e8lent que contrairement aux id\u00e9es re\u00e7ues, les maladies glom\u00e9rulaires primaires ne sont<\/p>\n","protected":false},"author":1,"featured_media":11501,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[2269,48,7587,49,619,248,157,1853,47,597],"class_list":["post-11500","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-consequences","tag-etude","tag-glomerulaire","tag-les","tag-long","tag-maladie","tag-revele","tag-tout","tag-une","tag-vie","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nUne \u00e9tude r\u00e9v\u00e8le les cons\u00e9quences de la maladie glom\u00e9rulaire tout au long de la vie - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/une-etude-revele-les-consequences-de-la-maladie-glomerulaire-tout-au-long-de-la-vie\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Une \u00e9tude r\u00e9v\u00e8le les cons\u00e9quences de la maladie glom\u00e9rulaire tout au long de la vie - 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