{"id":11486,"date":"2025-11-07T17:17:57","date_gmt":"2025-11-07T16:17:57","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/la-replication-du-coronavirus-repose-sur-une-enzyme-hote-nouvellement-identifiee-selon-une-etude\/"},"modified":"2025-11-07T17:18:01","modified_gmt":"2025-11-07T16:18:01","slug":"la-replication-du-coronavirus-repose-sur-une-enzyme-hote-nouvellement-identifiee-selon-une-etude","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/la-replication-du-coronavirus-repose-sur-une-enzyme-hote-nouvellement-identifiee-selon-une-etude\/","title":{"rendered":"La r\u00e9plication du coronavirus repose sur une enzyme h\u00f4te nouvellement identifi\u00e9e, selon une \u00e9tude"},"content":{"rendered":"
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Une \u00e9quipe de recherche de l\u2019Universit\u00e9 de la Ruhr \u00e0 Bochum, en Allemagne, a identifi\u00e9 un m\u00e9canisme cellulaire jusqu\u2019alors inconnu, crucial pour la r\u00e9plication des coronavirus : la kinase N-terminale c-Jun (JNK) est activ\u00e9e lors de l\u2019infection par le coronavirus humain HCoV-229E et intervient dans la phosphorylation de la prot\u00e9ine de la nucl\u00e9ocapside virale (N), une \u00e9tape essentielle dans le cycle du virus. Ces r\u00e9sultats aident \u00e0 mieux comprendre les interactions virus-h\u00f4te et pourraient ouvrir la voie \u00e0 de nouvelles approches pour explorer des strat\u00e9gies antivirales \u00e0 long terme.<\/p>\n

L’\u00e9quipe dirig\u00e9e par le Dr Yannick Br\u00fcggemann et le professeur Eike Steinmann rapportent leurs d\u00e9couvertes dans la revue Virus npj<\/i> \u00e0 partir du 18 septembre 2025.<\/p>\n

La production de virus diminue lorsque la kinase est bloqu\u00e9e<\/h2>\n

En utilisant la microscopie de cellules vivantes, l\u2019immunofluorescence quantitative et des analyses biochimiques, les chercheurs ont pu d\u00e9montrer que JNK est sp\u00e9cifiquement activ\u00e9 dans les cellules infect\u00e9es. Ils ont utilis\u00e9 un rapporteur de translocation de kinase (KTR) pour visualiser directement l’augmentation marqu\u00e9e de l’activit\u00e9 de JNK environ 16 heures apr\u00e8s l’infection. Si la kinase est bloqu\u00e9e par des inhibiteurs sp\u00e9cifiques, la production de virus est consid\u00e9rablement r\u00e9duite. C\u2019est le cas du HcoV-229E et du SARS-CoV-2.<\/p>\n

En coop\u00e9ration avec le groupe dirig\u00e9 par le professeur Michael Kracht de l’Universit\u00e9 de Giessen, l’\u00e9quipe a \u00e9galement pu montrer que JNK phosphoryle des r\u00e9sidus s\u00e9rine sp\u00e9cifiques sur la prot\u00e9ine N. Ces sites sont conserv\u00e9s dans divers coronavirus, ce qui indique que JNK joue un r\u00f4le commun dans la r\u00e9plication de divers types de virus.<\/p>\n

\u00ab\u00a0Nos donn\u00e9es mettent en \u00e9vidence JNK comme un facteur h\u00f4te important directement impliqu\u00e9 dans la modification de la prot\u00e9ine N, une \u00e9tape critique dans la r\u00e9plication du virus\u00a0\u00bb, explique Br\u00fcggemann.<\/p>\n

\u00ab\u00a0Le fait que l’inhibition de JNK entrave la r\u00e9plication du HCoV-229E et du SARS-CoV-2 montre le potentiel de cette voie de signal comme futur point de d\u00e9part pour de nouveaux agents antiviraux\u00a0\u00bb, ajoute Steinmann.<\/p>\n

<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

Une \u00e9quipe de recherche de l\u2019Universit\u00e9 de la Ruhr \u00e0 Bochum, en Allemagne, a identifi\u00e9<\/p>\n","protected":false},"author":1,"featured_media":11487,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[4451,5728,48,7582,2705,1631,2306,7581,46,112,47],"class_list":["post-11486","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-coronavirus","tag-enzyme","tag-etude","tag-hote","tag-identifiee","tag-nouvellement","tag-replication","tag-repose","tag-selon","tag-sur","tag-une","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nLa r\u00e9plication du coronavirus repose sur une enzyme h\u00f4te nouvellement identifi\u00e9e, selon une \u00e9tude - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/la-replication-du-coronavirus-repose-sur-une-enzyme-hote-nouvellement-identifiee-selon-une-etude\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"La r\u00e9plication du coronavirus repose sur une enzyme h\u00f4te nouvellement identifi\u00e9e, selon une \u00e9tude - 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