{"id":11420,"date":"2025-11-06T11:32:40","date_gmt":"2025-11-06T10:32:40","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/un-essai-clinique-a-un-stade-precoce-demontre-la-promesse-dun-vaccin-intranasal-contre-la-grippe-pour-generer-une-large-immunite\/"},"modified":"2025-11-06T11:32:40","modified_gmt":"2025-11-06T10:32:40","slug":"un-essai-clinique-a-un-stade-precoce-demontre-la-promesse-dun-vaccin-intranasal-contre-la-grippe-pour-generer-une-large-immunite","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/un-essai-clinique-a-un-stade-precoce-demontre-la-promesse-dun-vaccin-intranasal-contre-la-grippe-pour-generer-une-large-immunite\/","title":{"rendered":"Un essai clinique \u00e0 un stade pr\u00e9coce d\u00e9montre la promesse d\u2019un vaccin intranasal contre la grippe pour g\u00e9n\u00e9rer une large immunit\u00e9"},"content":{"rendered":"
\n
\n
\n
\n<\/figure><\/div>\n<\/div>\n

Des chercheurs du Centre pour le d\u00e9veloppement de vaccins et la sant\u00e9 mondiale (CVD) de l’\u00c9cole de m\u00e9decine de l’Universit\u00e9 du Maryland rapportent des r\u00e9sultats encourageants d’un essai clinique de premi\u00e8re phase qui a r\u00e9v\u00e9l\u00e9 qu’un vaccin intranasal exp\u00e9rimental d\u00e9clenchait une large r\u00e9ponse immunitaire contre plusieurs souches de la \u00ab grippe aviaire \u00bb H5N1.<\/p>\n

L’\u00e9tude, publi\u00e9e dans la revue Communications naturelles<\/i>met en \u00e9vidence le potentiel des strat\u00e9gies de vaccination des muqueuses \u2013 o\u00f9 les vaccins sont inject\u00e9s dans les narines \u2013 pour renforcer les d\u00e9fenses immunitaires contre diverses souches de grippe.<\/p>\n

\u00ab\u00a0La propagation de la grippe H5N1 chez les animaux avec des retomb\u00e9es sur les populations humaines \u00e0 l’\u00e9chelle mondiale met en \u00e9vidence le besoin critique de contre-mesures efficaces pour prot\u00e9ger nos communaut\u00e9s contre ce virus et d’autres agents pathog\u00e8nes \u00e0 potentiel pand\u00e9mique\u00a0\u00bb, a d\u00e9clar\u00e9 l’auteur correspondant de l’\u00e9tude Justin Ortiz, MD, MS, professeur de m\u00e9decine \u00e0 l’\u00c9cole de m\u00e9decine de l’Universit\u00e9 du Maryland (UMSOM) et chercheur en vaccins au CVD.<\/p>\n

\u00ab\u00a0Cet essai montre que ce vaccin intranasal et de longue conservation contre le H5N1 pourrait jouer un r\u00f4le majeur dans la pr\u00e9paration \u00e0 une pand\u00e9mie, offrant un moyen pratique et \u00e9volutif d’aider \u00e0 prot\u00e9ger les personnes contre les souches \u00e9volutives du virus.\u00a0\u00bb<\/p>\n

Les vaccins antigrippaux actuels, administr\u00e9s par voie intramusculaire, induisent principalement des r\u00e9ponses immunitaires syst\u00e9miques qui prot\u00e8gent contre la maladie symptomatique lorsqu’ils sont bien adapt\u00e9s aux souches en circulation. Cependant, ces vaccins pourraient \u00eatre moins efficaces pour pr\u00e9venir la propagation de l\u2019infection d\u2019une personne \u00e0 une autre. Les vaccins muqueux, administr\u00e9s par voie intranasale, visent \u00e0 stimuler l\u2019immunit\u00e9 au niveau du site d\u2019infection, offrant ainsi une approche prometteuse pour r\u00e9duire la transmission.<\/p>\n

Dans cet essai randomis\u00e9 et contr\u00f4l\u00e9, 40 volontaires adultes en bonne sant\u00e9 ont \u00e9t\u00e9 assign\u00e9s au hasard pour recevoir diff\u00e9rentes doses d’un vaccin contre la grippe H5 avec le NanoVax W de BlueWillow.80<\/sub>Adjuvant 5EC. Les groupes t\u00e9moins ont re\u00e7u un placebo ou une dose \u00e9lev\u00e9e du vaccin H5 sans adjuvant. Six mois plus tard, tous les volontaires ont re\u00e7u un rappel intramusculaire contre la grippe H5.<\/p>\n

Le vaccin intranasal NanoVax H5 s\u2019est av\u00e9r\u00e9 s\u00fbr et bien tol\u00e9r\u00e9. Il est important de noter que seules les personnes ayant re\u00e7u le vaccin nasal boost\u00e9 ont montr\u00e9 une forte \u00ab amor\u00e7age \u00bb immunitaire, ce qui signifie que leur syst\u00e8me immunitaire \u00e9tait activ\u00e9 et pr\u00eat \u00e0 r\u00e9pondre, comme cela a \u00e9t\u00e9 r\u00e9v\u00e9l\u00e9 plus tard, lorsqu’elles ont re\u00e7u une dose unique d’un vaccin intramusculaire contre la grippe H5.<\/p>\n

M\u00eame seul, sans rappel, le vaccin intranasal NanoVax H5 a d\u00e9clench\u00e9 les d\u00e9fenses immunitaires muqueuses et syst\u00e9miques \u2013 ce que d\u2019autres vaccins intranasaux recombinants contre la grippe H5 n\u2019ont pas r\u00e9ussi dans les essais cliniques.<\/p>\n

\u00ab\u00a0Le vaccin a \u00e9galement aid\u00e9 le syst\u00e8me immunitaire \u00e0 reconna\u00eetre plusieurs versions du virus H5N1, ce qui est essentiel car il existe diff\u00e9rentes versions du virus et elles changent avec le temps\u00a0\u00bb, a d\u00e9clar\u00e9 Meagan E. Deming, MD, Ph.D., co-auteur principal de l’\u00e9tude, professeur adjoint de m\u00e9decine \u00e0 l’UMSOM.<\/p>\n

\u00ab\u00a0L’utilisation de l’adjuvant sugg\u00e8re \u00e9galement que cette approche pourrait permettre d’utiliser des doses plus faibles du vaccin, ce qui pourrait rendre nos stocks de vaccins actuels accessibles \u00e0 un plus grand nombre de personnes en cas d’\u00e9pid\u00e9mie.\u00a0\u00bb<\/p>\n

Plus pr\u00e9cis\u00e9ment, l\u2019\u00e9tude a r\u00e9v\u00e9l\u00e9 que les volontaires ayant re\u00e7u le vaccin H5 avec adjuvant avaient une forte activit\u00e9 immunitaire, notamment des niveaux plus \u00e9lev\u00e9s d\u2019anticorps protecteurs (IgG et IgA), davantage de cellules immunitaires \u00e0 m\u00e9moire et une meilleure capacit\u00e9 \u00e0 tuer les cellules infect\u00e9es.<\/p>\n

\u00ab\u00a0Ces r\u00e9sultats d\u00e9montrent le succ\u00e8s de l’amor\u00e7age de la muqueuse et le potentiel d’une large immunit\u00e9 interclade\u00a0\u00bb, a d\u00e9clar\u00e9 le co-auteur principal de l’\u00e9tude, Franklin R. Toapanta, MD, Ph.D., professeur agr\u00e9g\u00e9 de m\u00e9decine \u00e0 l’UMSOM.<\/p>\n

\u00ab\u00a0La capacit\u00e9 du vaccin intranasal \u00e0 provoquer des r\u00e9ponses immunitaires muqueuses et cellulaires, associ\u00e9e \u00e0 une forte cytotoxicit\u00e9 cellulaire d\u00e9pendante des anticorps, souligne sa promesse dans le cadre des strat\u00e9gies de pr\u00e9vention de la grippe de nouvelle g\u00e9n\u00e9ration.\u00a0\u00bb<\/p>\n

\u00ab La recherche s’aligne sur les priorit\u00e9s mondiales de sant\u00e9 publique pour d\u00e9velopper des vaccins qui r\u00e9duisent la transmission et fournissent une protection plus large contre les souches \u00e9mergentes de grippe \u00bb, a d\u00e9clar\u00e9 Mark T. Gladwin, MD, doyen de l’\u00c9cole de m\u00e9decine de l’Universit\u00e9 du Maryland, vice-pr\u00e9sident des affaires m\u00e9dicales de l’Universit\u00e9 du Maryland, Baltimore, et professeur \u00e9m\u00e9rite John Z. et Akiko K. Bowers.<\/p>\n

\u00ab\u00a0Cela souligne \u00e9galement la n\u00e9cessit\u00e9 de poursuivre les recherches sur les biomarqueurs immunitaires des muqueuses et les corr\u00e9lats immunitaires alternatifs de protection, ce qui pourrait acc\u00e9l\u00e9rer le d\u00e9veloppement de vaccins intranasaux contre la grippe.\u00a0\u00bb<\/p>\n

<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

Des chercheurs du Centre pour le d\u00e9veloppement de vaccins et la sant\u00e9 mondiale (CVD) de<\/p>\n","protected":false},"author":1,"featured_media":3667,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[733,90,725,528,732,7299,419,7561,6240,3418,8,2555,4708,2692,47,323],"class_list":["post-11420","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-clinique","tag-contre","tag-demontre","tag-dun","tag-essai","tag-generer","tag-grippe","tag-immunite","tag-intranasal","tag-large","tag-pour","tag-precoce","tag-promesse","tag-stade","tag-une","tag-vaccin","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nUn essai clinique \u00e0 un stade pr\u00e9coce d\u00e9montre la promesse d\u2019un vaccin intranasal contre la grippe pour g\u00e9n\u00e9rer une large immunit\u00e9 - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/un-essai-clinique-a-un-stade-precoce-demontre-la-promesse-dun-vaccin-intranasal-contre-la-grippe-pour-generer-une-large-immunite\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Un essai clinique \u00e0 un stade pr\u00e9coce d\u00e9montre la promesse d\u2019un vaccin intranasal contre la grippe pour g\u00e9n\u00e9rer une large immunit\u00e9 - RVH-Synergie.org\" \/>\n<meta property=\"og:description\" content=\"Des chercheurs du Centre pour le d\u00e9veloppement de vaccins et la sant\u00e9 mondiale (CVD) de\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rvh-synergie.org\/actualites\/un-essai-clinique-a-un-stade-precoce-demontre-la-promesse-dun-vaccin-intranasal-contre-la-grippe-pour-generer-une-large-immunite\/\" \/>\n<meta property=\"og:site_name\" content=\"RVH-Synergie\" \/>\n<meta property=\"article:published_time\" content=\"2025-11-06T10:32:40+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/01\/1737334712_Le-baloxavir-un-antiviral-contre-la-grippe-semble-prometteur-par.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1285\" \/>\n\t<meta property=\"og:image:height\" content=\"1920\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Charles Martinez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"Charles Martinez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/un-essai-clinique-a-un-stade-precoce-demontre-la-promesse-dun-vaccin-intranasal-contre-la-grippe-pour-generer-une-large-immunite\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/un-essai-clinique-a-un-stade-precoce-demontre-la-promesse-dun-vaccin-intranasal-contre-la-grippe-pour-generer-une-large-immunite\/\"},\"author\":{\"name\":\"Charles Martinez\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/person\/aa5ea98671fb4e8620f488a0795d2560\"},\"headline\":\"Un essai clinique \u00e0 un stade pr\u00e9coce d\u00e9montre la promesse d\u2019un vaccin intranasal contre la grippe pour g\u00e9n\u00e9rer une large immunit\u00e9\",\"datePublished\":\"2025-11-06T10:32:40+00:00\",\"dateModified\":\"2025-11-06T10:32:40+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/un-essai-clinique-a-un-stade-precoce-demontre-la-promesse-dun-vaccin-intranasal-contre-la-grippe-pour-generer-une-large-immunite\/\"},\"wordCount\":888,\"publisher\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#organization\"},\"image\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/un-essai-clinique-a-un-stade-precoce-demontre-la-promesse-dun-vaccin-intranasal-contre-la-grippe-pour-generer-une-large-immunite\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/01\/1737334712_Le-baloxavir-un-antiviral-contre-la-grippe-semble-prometteur-par.jpg\",\"keywords\":[\"clinique\",\"contre\",\"d\u00e9montre\",\"dun\",\"essai\",\"g\u00e9n\u00e9rer\",\"grippe\",\"immunit\u00e9\",\"intranasal\",\"large\",\"pour\",\"pr\u00e9coce\",\"promesse\",\"stade\",\"une\",\"vaccin\"],\"articleSection\":[\"Les maladies\"],\"inLanguage\":\"fr-FR\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/un-essai-clinique-a-un-stade-precoce-demontre-la-promesse-dun-vaccin-intranasal-contre-la-grippe-pour-generer-une-large-immunite\/\",\"url\":\"https:\/\/rvh-synergie.org\/actualites\/un-essai-clinique-a-un-stade-precoce-demontre-la-promesse-dun-vaccin-intranasal-contre-la-grippe-pour-generer-une-large-immunite\/\",\"name\":\"Un essai clinique \u00e0 un stade pr\u00e9coce d\u00e9montre la promesse d\u2019un vaccin intranasal contre la grippe pour g\u00e9n\u00e9rer une large immunit\u00e9 - RVH-Synergie.org\",\"isPartOf\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/un-essai-clinique-a-un-stade-precoce-demontre-la-promesse-dun-vaccin-intranasal-contre-la-grippe-pour-generer-une-large-immunite\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/un-essai-clinique-a-un-stade-precoce-demontre-la-promesse-dun-vaccin-intranasal-contre-la-grippe-pour-generer-une-large-immunite\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/01\/1737334712_Le-baloxavir-un-antiviral-contre-la-grippe-semble-prometteur-par.jpg\",\"datePublished\":\"2025-11-06T10:32:40+00:00\",\"dateModified\":\"2025-11-06T10:32:40+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/un-essai-clinique-a-un-stade-precoce-demontre-la-promesse-dun-vaccin-intranasal-contre-la-grippe-pour-generer-une-large-immunite\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/rvh-synergie.org\/actualites\/un-essai-clinique-a-un-stade-precoce-demontre-la-promesse-dun-vaccin-intranasal-contre-la-grippe-pour-generer-une-large-immunite\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/un-essai-clinique-a-un-stade-precoce-demontre-la-promesse-dun-vaccin-intranasal-contre-la-grippe-pour-generer-une-large-immunite\/#primaryimage\",\"url\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/01\/1737334712_Le-baloxavir-un-antiviral-contre-la-grippe-semble-prometteur-par.jpg\",\"contentUrl\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/01\/1737334712_Le-baloxavir-un-antiviral-contre-la-grippe-semble-prometteur-par.jpg\",\"width\":1285,\"height\":1920,\"caption\":\"Le baloxavir, un antiviral contre la grippe, semble prometteur par rapport aux autres traitements pour les patients \u00e0 haut risque, raccourcissant la dur\u00e9e des sympt\u00f4mes\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/un-essai-clinique-a-un-stade-precoce-demontre-la-promesse-dun-vaccin-intranasal-contre-la-grippe-pour-generer-une-large-immunite\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/rvh-synergie.org\/actualites\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Un essai clinique \u00e0 un stade pr\u00e9coce d\u00e9montre la promesse d\u2019un vaccin intranasal contre la grippe pour g\u00e9n\u00e9rer une large immunit\u00e9\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#website\",\"url\":\"https:\/\/rvh-synergie.org\/actualites\/\",\"name\":\"RVH-Synergie.org\",\"description\":\"RVH-Synergie, site ind\u00e9pendant d'informations sur la prise en charge des addictions.\",\"publisher\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/rvh-synergie.org\/actualites\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#organization\",\"name\":\"RVH-Synergie.org\",\"url\":\"https:\/\/rvh-synergie.org\/actualites\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/favicon.png\",\"contentUrl\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/favicon.png\",\"width\":512,\"height\":512,\"caption\":\"RVH-Synergie.org\"},\"image\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/person\/aa5ea98671fb4e8620f488a0795d2560\",\"name\":\"Charles Martinez\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/charles-martinez-scaled.jpg\",\"contentUrl\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/charles-martinez-scaled.jpg\",\"caption\":\"Charles Martinez\"},\"description\":\"Bonjour, je m'appelle Charles Martinez, r\u00e9dacteur passionn\u00e9 pour le m\u00e9dia RVH-synergie.org, d\u00e9di\u00e9 aux addictions et aux maladies. Depuis plus de dix ans, j'explore et rapporte les histoires poignantes des individus confront\u00e9s \u00e0 ces d\u00e9fis, tout en sensibilisant le public aux traitements novateurs et aux progr\u00e8s scientifiques dans ce domaine. Mon engagement r\u00e9side dans l'espoir de cr\u00e9er une communaut\u00e9 inform\u00e9e et empathique, pr\u00eate \u00e0 soutenir ceux qui luttent contre ces \u00e9preuves.\",\"sameAs\":[\"https:\/\/rvh-synergie.org\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Un essai clinique \u00e0 un stade pr\u00e9coce d\u00e9montre la promesse d\u2019un vaccin intranasal contre la grippe pour g\u00e9n\u00e9rer une large immunit\u00e9 - RVH-Synergie.org","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/rvh-synergie.org\/actualites\/un-essai-clinique-a-un-stade-precoce-demontre-la-promesse-dun-vaccin-intranasal-contre-la-grippe-pour-generer-une-large-immunite\/","og_locale":"fr_FR","og_type":"article","og_title":"Un essai clinique \u00e0 un stade pr\u00e9coce d\u00e9montre la promesse d\u2019un vaccin intranasal contre la grippe pour g\u00e9n\u00e9rer une large immunit\u00e9 - RVH-Synergie.org","og_description":"Des chercheurs du Centre pour le d\u00e9veloppement de vaccins et la sant\u00e9 mondiale (CVD) de","og_url":"https:\/\/rvh-synergie.org\/actualites\/un-essai-clinique-a-un-stade-precoce-demontre-la-promesse-dun-vaccin-intranasal-contre-la-grippe-pour-generer-une-large-immunite\/","og_site_name":"RVH-Synergie","article_published_time":"2025-11-06T10:32:40+00:00","og_image":[{"width":1285,"height":1920,"url":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/01\/1737334712_Le-baloxavir-un-antiviral-contre-la-grippe-semble-prometteur-par.jpg","type":"image\/jpeg"}],"author":"Charles Martinez","twitter_card":"summary_large_image","twitter_misc":{"\u00c9crit par":"Charles Martinez","Dur\u00e9e de lecture estim\u00e9e":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/rvh-synergie.org\/actualites\/un-essai-clinique-a-un-stade-precoce-demontre-la-promesse-dun-vaccin-intranasal-contre-la-grippe-pour-generer-une-large-immunite\/#article","isPartOf":{"@id":"https:\/\/rvh-synergie.org\/actualites\/un-essai-clinique-a-un-stade-precoce-demontre-la-promesse-dun-vaccin-intranasal-contre-la-grippe-pour-generer-une-large-immunite\/"},"author":{"name":"Charles Martinez","@id":"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/person\/aa5ea98671fb4e8620f488a0795d2560"},"headline":"Un essai clinique \u00e0 un stade pr\u00e9coce d\u00e9montre la promesse d\u2019un vaccin intranasal contre la grippe pour g\u00e9n\u00e9rer une large immunit\u00e9","datePublished":"2025-11-06T10:32:40+00:00","dateModified":"2025-11-06T10:32:40+00:00","mainEntityOfPage":{"@id":"https:\/\/rvh-synergie.org\/actualites\/un-essai-clinique-a-un-stade-precoce-demontre-la-promesse-dun-vaccin-intranasal-contre-la-grippe-pour-generer-une-large-immunite\/"},"wordCount":888,"publisher":{"@id":"https:\/\/rvh-synergie.org\/actualites\/#organization"},"image":{"@id":"https:\/\/rvh-synergie.org\/actualites\/un-essai-clinique-a-un-stade-precoce-demontre-la-promesse-dun-vaccin-intranasal-contre-la-grippe-pour-generer-une-large-immunite\/#primaryimage"},"thumbnailUrl":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/01\/1737334712_Le-baloxavir-un-antiviral-contre-la-grippe-semble-prometteur-par.jpg","keywords":["clinique","contre","d\u00e9montre","dun","essai","g\u00e9n\u00e9rer","grippe","immunit\u00e9","intranasal","large","pour","pr\u00e9coce","promesse","stade","une","vaccin"],"articleSection":["Les maladies"],"inLanguage":"fr-FR"},{"@type":"WebPage","@id":"https:\/\/rvh-synergie.org\/actualites\/un-essai-clinique-a-un-stade-precoce-demontre-la-promesse-dun-vaccin-intranasal-contre-la-grippe-pour-generer-une-large-immunite\/","url":"https:\/\/rvh-synergie.org\/actualites\/un-essai-clinique-a-un-stade-precoce-demontre-la-promesse-dun-vaccin-intranasal-contre-la-grippe-pour-generer-une-large-immunite\/","name":"Un essai clinique \u00e0 un stade pr\u00e9coce d\u00e9montre la promesse d\u2019un vaccin intranasal contre la grippe pour g\u00e9n\u00e9rer une large immunit\u00e9 - RVH-Synergie.org","isPartOf":{"@id":"https:\/\/rvh-synergie.org\/actualites\/#website"},"primaryImageOfPage":{"@id":"https:\/\/rvh-synergie.org\/actualites\/un-essai-clinique-a-un-stade-precoce-demontre-la-promesse-dun-vaccin-intranasal-contre-la-grippe-pour-generer-une-large-immunite\/#primaryimage"},"image":{"@id":"https:\/\/rvh-synergie.org\/actualites\/un-essai-clinique-a-un-stade-precoce-demontre-la-promesse-dun-vaccin-intranasal-contre-la-grippe-pour-generer-une-large-immunite\/#primaryimage"},"thumbnailUrl":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/01\/1737334712_Le-baloxavir-un-antiviral-contre-la-grippe-semble-prometteur-par.jpg","datePublished":"2025-11-06T10:32:40+00:00","dateModified":"2025-11-06T10:32:40+00:00","breadcrumb":{"@id":"https:\/\/rvh-synergie.org\/actualites\/un-essai-clinique-a-un-stade-precoce-demontre-la-promesse-dun-vaccin-intranasal-contre-la-grippe-pour-generer-une-large-immunite\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/rvh-synergie.org\/actualites\/un-essai-clinique-a-un-stade-precoce-demontre-la-promesse-dun-vaccin-intranasal-contre-la-grippe-pour-generer-une-large-immunite\/"]}]},{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/rvh-synergie.org\/actualites\/un-essai-clinique-a-un-stade-precoce-demontre-la-promesse-dun-vaccin-intranasal-contre-la-grippe-pour-generer-une-large-immunite\/#primaryimage","url":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/01\/1737334712_Le-baloxavir-un-antiviral-contre-la-grippe-semble-prometteur-par.jpg","contentUrl":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/01\/1737334712_Le-baloxavir-un-antiviral-contre-la-grippe-semble-prometteur-par.jpg","width":1285,"height":1920,"caption":"Le baloxavir, un antiviral contre la grippe, semble prometteur par rapport aux autres traitements pour les patients \u00e0 haut risque, raccourcissant la dur\u00e9e des sympt\u00f4mes"},{"@type":"BreadcrumbList","@id":"https:\/\/rvh-synergie.org\/actualites\/un-essai-clinique-a-un-stade-precoce-demontre-la-promesse-dun-vaccin-intranasal-contre-la-grippe-pour-generer-une-large-immunite\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/rvh-synergie.org\/actualites\/"},{"@type":"ListItem","position":2,"name":"Un essai clinique \u00e0 un stade pr\u00e9coce d\u00e9montre la promesse d\u2019un vaccin intranasal contre la grippe pour g\u00e9n\u00e9rer une large immunit\u00e9"}]},{"@type":"WebSite","@id":"https:\/\/rvh-synergie.org\/actualites\/#website","url":"https:\/\/rvh-synergie.org\/actualites\/","name":"RVH-Synergie.org","description":"RVH-Synergie, site ind\u00e9pendant d'informations sur la prise en charge des addictions.","publisher":{"@id":"https:\/\/rvh-synergie.org\/actualites\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/rvh-synergie.org\/actualites\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"},{"@type":"Organization","@id":"https:\/\/rvh-synergie.org\/actualites\/#organization","name":"RVH-Synergie.org","url":"https:\/\/rvh-synergie.org\/actualites\/","logo":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/logo\/image\/","url":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/favicon.png","contentUrl":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/favicon.png","width":512,"height":512,"caption":"RVH-Synergie.org"},"image":{"@id":"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/person\/aa5ea98671fb4e8620f488a0795d2560","name":"Charles Martinez","image":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/person\/image\/","url":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/charles-martinez-scaled.jpg","contentUrl":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/charles-martinez-scaled.jpg","caption":"Charles Martinez"},"description":"Bonjour, je m'appelle Charles Martinez, r\u00e9dacteur passionn\u00e9 pour le m\u00e9dia RVH-synergie.org, d\u00e9di\u00e9 aux addictions et aux maladies. Depuis plus de dix ans, j'explore et rapporte les histoires poignantes des individus confront\u00e9s \u00e0 ces d\u00e9fis, tout en sensibilisant le public aux traitements novateurs et aux progr\u00e8s scientifiques dans ce domaine. Mon engagement r\u00e9side dans l'espoir de cr\u00e9er une communaut\u00e9 inform\u00e9e et empathique, pr\u00eate \u00e0 soutenir ceux qui luttent contre ces \u00e9preuves.","sameAs":["https:\/\/rvh-synergie.org\/"]}]}},"_links":{"self":[{"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/posts\/11420","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/comments?post=11420"}],"version-history":[{"count":0,"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/posts\/11420\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/media\/3667"}],"wp:attachment":[{"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/media?parent=11420"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/categories?post=11420"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/tags?post=11420"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}