{"id":11388,"date":"2025-11-05T19:21:34","date_gmt":"2025-11-05T18:21:34","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/criteres-de-classification-pour-larthropathie-hemochromatose-developpes\/"},"modified":"2025-11-05T19:21:36","modified_gmt":"2025-11-05T18:21:36","slug":"criteres-de-classification-pour-larthropathie-hemochromatose-developpes","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/criteres-de-classification-pour-larthropathie-hemochromatose-developpes\/","title":{"rendered":"Crit\u00e8res de classification pour l’arthropathie h\u00e9mochromatose d\u00e9velopp\u00e9s"},"content":{"rendered":"
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L’Alliance europ\u00e9enne des associations de rhumatologie a d\u00e9velopp\u00e9 les premiers crit\u00e8res de classification de l’arthropathie h\u00e9mochromatose (HA) \u00e0 partir d’une cohorte de d\u00e9rivation unique utilisant une m\u00e9thodologie rigoureuse. L\u2019HA est une arthropathie distinctive associ\u00e9e \u00e0 une h\u00e9mochromatose g\u00e9n\u00e9tique, une affection dans laquelle les niveaux de fer s\u2019accumulent au fil du temps. Cela a de nombreuses cons\u00e9quences, notamment la cirrhose du foie, le diab\u00e8te et une arthropathie particuli\u00e8re.<\/p>\n

Les cas sont le plus souvent signal\u00e9s chez les personnes pr\u00e9sentant un taux \u00e9lev\u00e9 de ferritine et une mutation homozygote C282Y du g\u00e8ne HFE. Mais \u00e0 l\u2019heure actuelle, il existe un manque de connaissances sur la pathogen\u00e8se et davantage d\u2019informations sont n\u00e9cessaires sur le lien entre les mutations g\u00e9n\u00e9tiques, la carence en hepcidine, la charge en fer et les maladies articulaires. Il convient de noter qu\u2019il n\u2019existe aucun crit\u00e8re de classification pour l\u2019HA, ce qui a limit\u00e9 les recherches sur cette arthropathie.<\/p>\n

Pour combler ces lacunes, EULAR a constitu\u00e9 un groupe de travail compos\u00e9 de professionnels de la sant\u00e9 et de patients partenaires de recherche. Le projet comportait trois phases, con\u00e7ues pour examiner les caract\u00e9ristiques de l’HA et cr\u00e9er des crit\u00e8res de classification possibles, avant de les tester chez des personnes atteintes d’HA connues, ainsi que dans un groupe t\u00e9moin de personnes atteintes d’autres maladies tr\u00e8s similaires, telles que l’arthrose g\u00e9n\u00e9ralis\u00e9e et la maladie des d\u00e9p\u00f4ts de pyrophosphate de calcium. L’article est publi\u00e9 dans la revue Annales des maladies rhumatismales<\/i>.<\/p>\n

Le r\u00e9sultat a \u00e9t\u00e9 un mod\u00e8le de classification bas\u00e9 sur des points qui peut \u00eatre utilis\u00e9 chez les personnes souffrant de douleurs articulaires, ainsi que la mutation homozygote HFE C282Y et les preuves ant\u00e9rieures de charge en fer. Le mod\u00e8le utilise huit variables qui couvrent l’\u00e2ge au d\u00e9but des sympt\u00f4mes, les caract\u00e9ristiques cliniques et radiographiques des articulations m\u00e9tacarpo-phalangiennes, interphalangiennes distales et de la cheville, ainsi que les ant\u00e9c\u00e9dents de chirurgie \u00e0 la hanche ou \u00e0 la cheville.<\/p>\n

Chacun de ces \u00e9l\u00e9ments est facilement \u00e9valu\u00e9 dans la pratique clinique de routine et, ensemble, ils sont consid\u00e9r\u00e9s comme les meilleurs discriminateurs par rapport aux imitations de maladies. Pour atteindre ce seuil, une personne doit obtenir au moins 5 sur 11, sur un minimum de trois crit\u00e8res. Cette approche, qui repr\u00e9sente le premier crit\u00e8re de classification destin\u00e9 \u00e0 \u00eatre utilis\u00e9 dans ce groupe de personnes, offre une sp\u00e9cificit\u00e9 de 93,3\u00a0% et une sensibilit\u00e9 de 71,4\u00a0% pour la classification en HA.<\/p>\n

\u00ab\u00a0Nous sommes ravis d’avoir produit les premiers crit\u00e8res de classification pour cette arthropathie tr\u00e8s n\u00e9glig\u00e9e et mal comprise\u00a0\u00bb, a d\u00e9clar\u00e9 Patrick Kiely, auteur principal de l’article et professeur de pratique clinique en rhumatologie \u00e0 l’h\u00f4pital universitaire St George de Londres, au Royaume-Uni.<\/p>\n

\u00ab\u00a0Nous esp\u00e9rons que cela stimulera un regain d’int\u00e9r\u00eat universitaire et des essais de bonne qualit\u00e9 pour faire progresser notre compr\u00e9hension de cette maladie et, \u00e0 terme, d\u00e9velopper de nouveaux traitements pour arr\u00eater la progression des maladies articulaires chez ces personnes.\u00a0\u00bb<\/p>\n

Les crit\u00e8res ne sont pas diagnostiques et ne doivent \u00eatre utilis\u00e9s que pour recruter des patients pour des \u00e9tudes de recherche. Bien qu’une validation externe dans des cohortes distinctes soit encore n\u00e9cessaire, EULAR esp\u00e8re que ce d\u00e9veloppement sensibilisera et stimulera l’int\u00e9r\u00eat et la recherche et, \u00e0 terme, soutiendra de nouvelles options de traitement pour les patients \u00e0 l’avenir.<\/p>\n

\t\t\t\t\t\t\t\t\t\t\t\tFourni par l’Alliance europ\u00e9enne des associations de rhumatologie<\/p>\n

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L’Alliance europ\u00e9enne des associations de rhumatologie a d\u00e9velopp\u00e9 les premiers crit\u00e8res de classification de l’arthropathie<\/p>\n","protected":false},"author":1,"featured_media":11389,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[3631,5648,7546,7545,7544,8],"class_list":["post-11388","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-classification","tag-criteres","tag-developpes","tag-hemochromatose","tag-larthropathie","tag-pour","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nCrit\u00e8res de classification pour l'arthropathie h\u00e9mochromatose d\u00e9velopp\u00e9s - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/criteres-de-classification-pour-larthropathie-hemochromatose-developpes\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Crit\u00e8res de classification pour l'arthropathie h\u00e9mochromatose d\u00e9velopp\u00e9s - 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