{"id":1138,"date":"2024-10-08T06:56:13","date_gmt":"2024-10-08T04:56:13","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/le-bimekizumab-est-sur-et-efficace-sur-deux-ans-dans-le-traitement-de-lhidrosadenite-suppuree\/"},"modified":"2024-10-08T06:56:15","modified_gmt":"2024-10-08T04:56:15","slug":"le-bimekizumab-est-sur-et-efficace-sur-deux-ans-dans-le-traitement-de-lhidrosadenite-suppuree","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/le-bimekizumab-est-sur-et-efficace-sur-deux-ans-dans-le-traitement-de-lhidrosadenite-suppuree\/","title":{"rendered":"Le bimekizumab est s\u00fbr et efficace sur deux ans dans le traitement de l’hidrosad\u00e9nite suppur\u00e9e"},"content":{"rendered":"
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Pour les patients atteints d’hidrad\u00e9nite suppur\u00e9e (HS), le bimekizumab est s\u00fbr et efficace sur deux ans, selon une \u00e9tude pr\u00e9sent\u00e9e lors de la r\u00e9union annuelle de l’Acad\u00e9mie europ\u00e9enne de dermatologie et de v\u00e9n\u00e9r\u00e9ologie, tenue du 25 au 28 septembre \u00e0 Amsterdam.<\/p>\n

Christos C. Zouboulis, de la Fondation europ\u00e9enne de l’hidrad\u00e9nite suppur\u00e9e \u00e0 Dessau, en Allemagne, et ses coll\u00e8gues ont pr\u00e9sent\u00e9 les donn\u00e9es d’efficacit\u00e9 et de s\u00e9curit\u00e9 sur deux ans pour les essais regroup\u00e9s BE HEARD I&II (BHI&II) et BE HEARD EXT (BHEXT). Au total, 556 patients ont \u00e9t\u00e9 assign\u00e9s au hasard au bimekizumab dans l’\u00e9tude BHI&II au d\u00e9part, ont compl\u00e9t\u00e9 48 semaines et sont entr\u00e9s dans BHEXT\u00a0; 446 ont compl\u00e9t\u00e9 96 semaines en BHEXT.<\/p>\n

Les chercheurs ont constat\u00e9 qu’une r\u00e9ponse clinique HS \u2265 50\u00a0% (HiSCR50)\/75\/90\/100 a \u00e9t\u00e9 obtenue par 79,9, 64,0, 42,3 et 30,2\u00a0% de tous les patients trait\u00e9s par bimekizumab, respectivement, \u00e0 la semaine 48\u00a0; il y a eu une am\u00e9lioration des r\u00e9ponses \u00e0 85,4, 77,1, 57,6 et 44,2 %, respectivement, \u00e0 la semaine 96. Le score moyen du syst\u00e8me international HS Severity Score System (IHS4) chez les patients trait\u00e9s par bimekizumab \u00e9tait de 35,6 \u00b1 31,5 au d\u00e9part\u00a0; le pourcentage de variation moyen par rapport au d\u00e9part dans IHS4 \u00e9tait de \u221270,3 \u00b1 39,6 et de \u221279,8 \u00b1 28,1 aux semaines 48 et 96, respectivement.<\/p>\n

Le nombre moyen de tunnels de drainage (DT) \u00e9tait de 3,8 \u00b1 4,3 chez les patients trait\u00e9s par bimekizumab au d\u00e9part\u00a0; la variation moyenne en pourcentage par rapport \u00e0 la valeur initiale des DT \u00e9tait de \u221257,5 \u00b1 72,9 et de \u221273,7 \u00b1 45,7 aux semaines 48 et 96, respectivement. Au total, 917 des 995 patients ayant re\u00e7u une ou plusieurs doses de bimekizumab ont pr\u00e9sent\u00e9 un \u00e9v\u00e9nement ind\u00e9sirable survenu pendant le traitement (EIT) sur une p\u00e9riode de deux ans. Des EIIT graves ont \u00e9t\u00e9 rapport\u00e9s chez 122 patients et des EIIT ayant conduit \u00e0 l’arr\u00eat du traitement ont \u00e9t\u00e9 rapport\u00e9s chez 109 patients.<\/p>\n

\u00ab\u00a0Ces r\u00e9sultats sont particuli\u00e8rement encourageants compte tenu de la n\u00e9cessit\u00e9 de nouvelles options de traitement offrant un soulagement durable aux patients\u00a0\u00bb, a d\u00e9clar\u00e9 Zouboulis dans un communiqu\u00e9.<\/p>\n

<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

Pour les patients atteints d’hidrad\u00e9nite suppur\u00e9e (HS), le bimekizumab est s\u00fbr et efficace sur deux<\/p>\n","protected":false},"author":1,"featured_media":1139,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[38,1464,44,273,206,223,1465,1466,112,261],"class_list":["post-1138","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-ans","tag-bimekizumab","tag-dans","tag-deux","tag-efficace","tag-est","tag-lhidrosadenite","tag-suppuree","tag-sur","tag-traitement","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nLe bimekizumab est s\u00fbr et efficace sur deux ans dans le traitement de l'hidrosad\u00e9nite suppur\u00e9e - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/le-bimekizumab-est-sur-et-efficace-sur-deux-ans-dans-le-traitement-de-lhidrosadenite-suppuree\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Le bimekizumab est s\u00fbr et efficace sur deux ans dans le traitement de l'hidrosad\u00e9nite suppur\u00e9e - 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