{"id":11188,"date":"2025-10-31T02:36:20","date_gmt":"2025-10-31T01:36:20","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/une-etude-montre-la-protection-vaccinale-contre-linfection-a-salmonella-paratyphi-a\/"},"modified":"2025-10-31T02:36:21","modified_gmt":"2025-10-31T01:36:21","slug":"une-etude-montre-la-protection-vaccinale-contre-linfection-a-salmonella-paratyphi-a","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/une-etude-montre-la-protection-vaccinale-contre-linfection-a-salmonella-paratyphi-a\/","title":{"rendered":"Une \u00e9tude montre la protection vaccinale contre l\u2019infection \u00e0 Salmonella Paratyphi A"},"content":{"rendered":"
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Une \u00e9tude men\u00e9e par Oxford a d\u00e9montr\u00e9 qu’un vaccin oral vivant att\u00e9nu\u00e9, CVD 1902, offrait une protection significative contre l’infection \u00e0 S. Paratyphi A chez des adultes en bonne sant\u00e9 en utilisant un mod\u00e8le d’infection humaine contr\u00f4l\u00e9, sans aucun probl\u00e8me de s\u00e9curit\u00e9. La recherche est publi\u00e9e dans le Journal de m\u00e9decine de la Nouvelle-Angleterre<\/i>.<\/p>\n

La fi\u00e8vre ent\u00e9rique, caus\u00e9e par Salmonella Typhi et Salmonella Paratyphi, entra\u00eene chaque ann\u00e9e plus de 100 000 d\u00e9c\u00e8s et plus de 8 millions d’ann\u00e9es de vie ajust\u00e9es sur l’incapacit\u00e9. Environ 30 % des cas, soit plus de 2 millions par an, sont caus\u00e9s par S. Paratyphi A, pour laquelle aucun vaccin n’est actuellement disponible.<\/p>\n

L’essai de phase 2b randomis\u00e9, en double aveugle et contr\u00f4l\u00e9 par placebo, men\u00e9 par l’Oxford Vaccine Group (D\u00e9partement de p\u00e9diatrie, Universit\u00e9 d’Oxford) sur six sites britanniques, a recrut\u00e9 72 volontaires adultes en bonne sant\u00e9 \u00e2g\u00e9s de 18 \u00e0 55 ans.<\/p>\n

Les participants ont re\u00e7u deux doses orales du vaccin CVD 1902 ou un placebo, administr\u00e9es \u00e0 14 jours d’intervalle. Quatre semaines apr\u00e8s la deuxi\u00e8me dose, ils ont \u00e9t\u00e9 d\u00e9lib\u00e9r\u00e9ment expos\u00e9s \u00e0 S. Paratyphi A dans des conditions soigneusement surveill\u00e9es pour \u00e9valuer la protection.<\/p>\n

Dans les 14 jours suivant la provocation, 21 % des participants du groupe vaccin\u00e9 et 75 % des participants du groupe placebo ont re\u00e7u un diagnostic d’infection, ce qui \u00e9quivaut \u00e0 une efficacit\u00e9 du vaccin de 73 % (IC \u00e0 95 %, 46-86).<\/p>\n

Aucun \u00e9v\u00e9nement ind\u00e9sirable grave li\u00e9 au vaccin n\u2019a \u00e9t\u00e9 identifi\u00e9 et les effets secondaires \u00e9taient g\u00e9n\u00e9ralement l\u00e9gers \u00e0 mod\u00e9r\u00e9s dans les deux groupes.<\/p>\n

Le Dr Naina McCann, chercheuse clinique \u00e0 l’Oxford Vaccine Group et auteur principal, a d\u00e9clar\u00e9 : \u00ab C’est la premi\u00e8re fois qu’il est d\u00e9montr\u00e9 qu’un vaccin moderne prot\u00e8ge les gens contre Salmonella Paratyphi A, une maladie qui touche des millions de personnes chaque ann\u00e9e.<\/p>\n

Le professeur Sir Andrew Pollard, directeur de l’Oxford Vaccine Group et co-auteur principal, a d\u00e9clar\u00e9 : \u00ab Nous sommes dans une lutte constante contre les infections bact\u00e9riennes, comme la paratypho\u00efde, qui menacent la vie des enfants dans certaines des r\u00e9gions du monde les plus pauvres en ressources. Cette \u00e9tude donne l’espoir que cette maladie importante pourrait \u00eatre contr\u00f4l\u00e9e par la vaccination si les m\u00eames effets peuvent \u00eatre obtenus dans des conditions r\u00e9elles dans ces communaut\u00e9s.<\/p>\n

Le professeur Xinxue Liu, professeur agr\u00e9g\u00e9 de statistiques m\u00e9dicales et d’\u00e9pid\u00e9miologie \u00e0 l’Oxford Vaccine Group et co-auteur principal, a d\u00e9clar\u00e9 : \u00ab Bien que des vaccins conjugu\u00e9s contre la typho\u00efde aient \u00e9t\u00e9 introduits dans huit pays, il n’existe actuellement aucun vaccin autoris\u00e9 contre la fi\u00e8vre paratypho\u00efde.<\/p>\n

\u00ab Notre \u00e9tude marque une \u00e9tape importante vers le d\u00e9veloppement de vaccins contre la paratypho\u00efde dans le cadre d’efforts plus larges visant \u00e0 contr\u00f4ler la fi\u00e8vre ent\u00e9rique. Oxford m\u00e8ne actuellement des \u00e9tudes suppl\u00e9mentaires \u00e9valuant deux nouveaux vaccins candidats bivalents conjugu\u00e9s typho\u00efde-paratypho\u00efde, dans le but d’acc\u00e9l\u00e9rer les progr\u00e8s vers une pr\u00e9vention globale de la fi\u00e8vre ent\u00e9rique \u00e0 l’\u00e9chelle mondiale.<\/p>\n

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Une \u00e9tude men\u00e9e par Oxford a d\u00e9montr\u00e9 qu’un vaccin oral vivant att\u00e9nu\u00e9, CVD 1902, offrait<\/p>\n","protected":false},"author":1,"featured_media":485,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[90,48,539,210,7412,1116,3240,47,707],"class_list":["post-11188","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-contre","tag-etude","tag-linfection","tag-montre","tag-paratyphi","tag-protection","tag-salmonella","tag-une","tag-vaccinale","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nUne \u00e9tude montre la protection vaccinale contre l\u2019infection \u00e0 Salmonella Paratyphi A - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/une-etude-montre-la-protection-vaccinale-contre-linfection-a-salmonella-paratyphi-a\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Une \u00e9tude montre la protection vaccinale contre l\u2019infection \u00e0 Salmonella Paratyphi A - 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