{"id":11001,"date":"2025-10-24T22:25:24","date_gmt":"2025-10-24T20:25:24","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/comprendre-comment-le-paludisme-cerebral-brise-la-barriere-hemato-encephalique\/"},"modified":"2025-10-24T22:25:25","modified_gmt":"2025-10-24T20:25:25","slug":"comprendre-comment-le-paludisme-cerebral-brise-la-barriere-hemato-encephalique","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/comprendre-comment-le-paludisme-cerebral-brise-la-barriere-hemato-encephalique\/","title":{"rendered":"Comprendre comment le paludisme c\u00e9r\u00e9bral brise la barri\u00e8re h\u00e9mato-enc\u00e9phalique"},"content":{"rendered":"
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Des chercheurs ont construit une barri\u00e8re h\u00e9mato-enc\u00e9phalique humaine en 3D en laboratoire et ont d\u00e9couvert le r\u00f4le cl\u00e9 des p\u00e9ricytes c\u00e9r\u00e9braux dans le paludisme c\u00e9r\u00e9bral<\/p>\n

Le paludisme c\u00e9r\u00e9bral est une complication mortelle de l’infection \u00e0 Plasmodium falciparum. Malgr\u00e9 des recherches de pointe, des m\u00e9dicaments antipaludiques efficaces et la promesse d\u2019un vaccin, le paludisme fait encore plus d\u2019un demi-million de morts chaque ann\u00e9e. De nombreux survivants du paludisme c\u00e9r\u00e9bral souffrent de handicaps \u00e0 long terme tels que l’\u00e9pilepsie, des troubles de la parole ou des difficult\u00e9s de mouvement.<\/p>\n

Dans une nouvelle \u00e9tude publi\u00e9e dans EMBO M\u00e9decine Mol\u00e9culaire<\/i>des chercheurs de l’EMBL Barcelone mettent en \u00e9vidence la perturbation des p\u00e9ricytes (cellules pr\u00e9sentes le long des parois des capillaires) induite par le paludisme, nous rapprochant ainsi de la compr\u00e9hension de la mani\u00e8re dont le paludisme c\u00e9r\u00e9bral endommage le cerveau et de la mani\u00e8re dont ces dommages pourraient \u00eatre \u00e9vit\u00e9s ou invers\u00e9s.<\/p>\n

L’infection par le paludisme c\u00e9r\u00e9bral provoque de graves dommages aux vaisseaux sanguins d\u00e9licats du cerveau. Un acteur central de ces dommages est la voie de signalisation angiopo\u00ef\u00e9tine-Tie, qui aide normalement les vaisseaux sanguins \u00e0 rester stables, serr\u00e9s et prot\u00e9g\u00e9s.<\/p>\n

Le fonctionnement normal de cette voie d\u00e9pend de la s\u00e9cr\u00e9tion d’une mol\u00e9cule appel\u00e9e angiopo\u00ef\u00e9tine-1 (Ang-1) par les p\u00e9ricytes. Les patients atteints de paludisme c\u00e9r\u00e9bral pr\u00e9sentent souvent un d\u00e9s\u00e9quilibre dans cette voie : trop de mol\u00e9cule d\u00e9stabilisante angiopo\u00ef\u00e9tine-2 et trop peu d’Ang-1 protecteur.<\/p>\n

\u00ab\u00a0Dans cette \u00e9tude, nous avons g\u00e9n\u00e9r\u00e9 un mod\u00e8le microvasculaire avanc\u00e9 du cerveau humain 3D qui reproduit d’importantes interactions in vivo entre les cellules endoth\u00e9liales du cerveau humain et les p\u00e9ricytes\u00a0\u00bb, a d\u00e9clar\u00e9 Rory Long, chercheur postdoctoral au sein du groupe Bernabeu de l’EMBL Barcelone et premier auteur du travail.<\/p>\n

\u00ab\u00a0Nous montrons que la perturbation du r\u00f4le crucial des p\u00e9ricytes dans la protection et la restauration des vaisseaux sanguins favorise les l\u00e9sions de la barri\u00e8re h\u00e9mato-enc\u00e9phalique lors du paludisme c\u00e9r\u00e9bral.\u00a0\u00bb<\/p>\n

L’\u00e9quipe de chercheurs a construit une barri\u00e8re h\u00e9mato-enc\u00e9phalique humaine en 3D sur une puce et a recr\u00e9\u00e9 les caract\u00e9ristiques cl\u00e9s de l’environnement vasculaire (li\u00e9 aux vaisseaux sanguins) du cerveau.<\/p>\n

Lorsqu\u2019ils ont expos\u00e9 ce mod\u00e8le aux sous-produits du parasite du paludisme, la s\u00e9cr\u00e9tion d\u2019Ang-1 a \u00e9t\u00e9 stopp\u00e9e, les vaisseaux ont commenc\u00e9 \u00e0 fuir et les p\u00e9ricytes eux-m\u00eames ont pr\u00e9sent\u00e9 des dommages subtils. Lorsque les chercheurs ont rajout\u00e9 de l’Ang-1, ils ont pu restaurer partiellement la stabilit\u00e9 vasculaire, mettant en \u00e9vidence un lien entre la diminution de la s\u00e9cr\u00e9tion d’Ang-1 et la rupture de la barri\u00e8re h\u00e9mato-enc\u00e9phalique.<\/p>\n

Pour r\u00e9pondre au besoin urgent de nouveaux traitements d’appoint contre le paludisme c\u00e9r\u00e9bral, les auteurs ont ensuite examin\u00e9 le potentiel th\u00e9rapeutique de la voie angiopo\u00ef\u00e9tine-Tie en utilisant l’AKB-9778, un m\u00e9dicament qui stimule l’activit\u00e9 Tie-2 et qui fait actuellement l’objet d’essais cliniques pour la r\u00e9tinopathie diab\u00e9tique.<\/p>\n

Ils ont d\u00e9couvert qu’un court pr\u00e9traitement du mod\u00e8le 3D de barri\u00e8re h\u00e9mato-enc\u00e9phalique avec l’AKB-9778 emp\u00eachait partiellement les globules rouges infect\u00e9s par le paludisme de perturber l’int\u00e9grit\u00e9 du syst\u00e8me vasculaire. Par cons\u00e9quent, cette \u00e9tude a identifi\u00e9 l\u2019AKB-9778 et, plus largement, la restauration de la fonction hom\u00e9ostatique des p\u00e9ricytes comme une nouvelle voie passionnante dans le traitement du paludisme c\u00e9r\u00e9bral.<\/p>\n

\u00ab Notre mod\u00e8le vasculaire de bio-ing\u00e9nierie constitue une plateforme physiologiquement pertinente pour tester des th\u00e9rapies suppl\u00e9mentaires contre le paludisme c\u00e9r\u00e9bral \u00bb, a d\u00e9clar\u00e9 Maria Bernabeu, responsable du groupe EMBL et auteur principal de la publication.<\/p>\n

\u00ab\u00a0Les \u00e9tudes exp\u00e9rimentales sur les rongeurs ne sont pas id\u00e9ales pour la d\u00e9couverte th\u00e9rapeutique, car le paludisme affecte diff\u00e9remment les esp\u00e8ces. Nos r\u00e9sultats ouvrent la voie \u00e0 l’identification de nouveaux traitements pour les patients atteints de paludisme c\u00e9r\u00e9bral.\u00a0\u00bb<\/p>\n

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Des chercheurs ont construit une barri\u00e8re h\u00e9mato-enc\u00e9phalique humaine en 3D en laboratoire et ont d\u00e9couvert<\/p>\n","protected":false},"author":1,"featured_media":11002,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[3072,7333,879,182,310,5036,866],"class_list":["post-11001","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-barriere","tag-brise","tag-cerebral","tag-comment","tag-comprendre","tag-hematoencephalique","tag-paludisme","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nComprendre comment le paludisme c\u00e9r\u00e9bral brise la barri\u00e8re h\u00e9mato-enc\u00e9phalique - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/comprendre-comment-le-paludisme-cerebral-brise-la-barriere-hemato-encephalique\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Comprendre comment le paludisme c\u00e9r\u00e9bral brise la barri\u00e8re h\u00e9mato-enc\u00e9phalique - 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