{"id":10444,"date":"2025-10-09T17:27:42","date_gmt":"2025-10-09T15:27:42","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/les-structures-proteiques-elucidees-du-parasite-du-paludisme-offrent-des-opportunites-pour-de-nouveaux-vaccins\/"},"modified":"2025-10-09T17:27:42","modified_gmt":"2025-10-09T15:27:42","slug":"les-structures-proteiques-elucidees-du-parasite-du-paludisme-offrent-des-opportunites-pour-de-nouveaux-vaccins","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/les-structures-proteiques-elucidees-du-parasite-du-paludisme-offrent-des-opportunites-pour-de-nouveaux-vaccins\/","title":{"rendered":"Les structures prot\u00e9iques \u00e9lucid\u00e9es du parasite du paludisme offrent des opportunit\u00e9s pour de nouveaux vaccins"},"content":{"rendered":"
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\u00c0 l\u2019aide de millions d\u2019images microscopiques agrandies jusqu\u2019\u00e0 130\u00a0000 fois, des chercheurs du centre m\u00e9dical de l\u2019universit\u00e9 Radboud et de Toronto ont d\u00e9couvert la structure de deux prot\u00e9ines cl\u00e9s du parasite du paludisme. Forts de ces connaissances, les scientifiques d\u00e9veloppent de nouveaux vaccins qui bloquent la transmission des parasites via les moustiques.<\/p>\n

Le paludisme, une maladie infectieuse parasitaire, existe depuis l’\u00e9poque des anciens \u00c9gyptiens et menace encore pr\u00e8s de la moiti\u00e9 de la population mondiale.<\/p>\n

Ces derni\u00e8res ann\u00e9es, deux vaccins contre le paludisme sont devenus disponibles pour prot\u00e9ger contre l\u2019infection, mais ils n\u2019offrent pas une protection compl\u00e8te. De plus, ces vaccins n\u2019arr\u00eatent pas la propagation du parasite du paludisme d\u2019une personne \u00e0 l\u2019autre via les moustiques. C’est pourquoi les chercheurs travaillent sur de nouveaux vaccins qui bloquent cette transmission.<\/p>\n

30 milliards de parasites<\/h2>\n

Ces nouveaux vaccins ciblent principalement deux prot\u00e9ines du parasite du paludisme. \u00ab\u00a0Ces prot\u00e9ines ont \u00e9t\u00e9 d\u00e9couvertes dans les ann\u00e9es 1980, mais nous ne savions pas encore vraiment \u00e0 quoi elles ressemblaient\u00a0\u00bb, explique le docteur. candidat Ezra Bekkering de Radboudumc. \u00ab\u00a0C’est parce qu’ils sont difficiles \u00e0 produire.\u00a0\u00bb<\/p>\n

Bekkering et ses coll\u00e8gues, en collaboration avec des scientifiques du Hospital for Sick Children Research Institute de Toronto, ont enfin d\u00e9couvert les structures de ces deux prot\u00e9ines et publi\u00e9 leurs r\u00e9sultats dans la revue Immunit\u00e9<\/i>.<\/p>\n

Pour les analyser, les chercheurs devaient obtenir suffisamment de prot\u00e9ines. Pour ce faire, ils ont cultiv\u00e9 trente milliards de parasites du paludisme, un processus qui a dur\u00e9 six mois. Ils ont extrait les prot\u00e9ines des parasites puis ont r\u00e9solu leur structure 3D par cryomicroscopie \u00e9lectronique. Cette technique permet de visualiser les prot\u00e9ines au niveau atomique en prenant des millions d’images avec un microscope pouvant zoomer jusqu’\u00e0 130 000 fois.<\/p>\n

Reproduction sexu\u00e9e<\/h2>\n

Bien que la structure des prot\u00e9ines soit d\u00e9sormais \u00e9lucid\u00e9e, leur r\u00f4le reste quelque peu myst\u00e9rieux. Le chercheur Matthijs Jore explique : \u00ab Elles font partie d’un complexe \u00e0 la surface du parasite du paludisme et sont sp\u00e9cifiques \u00e0 cet agent pathog\u00e8ne. Cela en fait une cible appropri\u00e9e pour les vaccins. Ces prot\u00e9ines aident probablement le parasite lors de la reproduction sexu\u00e9e. \u00bb<\/p>\n

Maintenant que les chercheurs connaissent la structure 3D des deux prot\u00e9ines, ils comprennent mieux comment le parasite du paludisme infecte les moustiques et comment les anticorps dirig\u00e9s contre ces prot\u00e9ines peuvent bloquer le d\u00e9veloppement du parasite chez le moustique. Ils peuvent d\u00e9sormais utiliser cette structure comme mod\u00e8le pour d\u00e9velopper de nouveaux vaccins contre le paludisme qui contribueront \u00e0 \u00e9radiquer cette maladie mortelle.<\/p>\n

Jore ajoute : \u00ab Si vous ne savez pas \u00e0 quoi ressemble quelque chose, il est difficile de vous en prot\u00e9ger. Les structures \u00e9lucid\u00e9es offrent de nouvelles opportunit\u00e9s pour de meilleurs vaccins contre le paludisme. \u00bb<\/p>\n

<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

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