{"id":10364,"date":"2025-10-07T17:58:47","date_gmt":"2025-10-07T15:58:47","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/detection-du-syndrome-dalport-par-le-biais-dun-depistage-durine-universel-de-3-ans\/"},"modified":"2025-10-07T17:58:51","modified_gmt":"2025-10-07T15:58:51","slug":"detection-du-syndrome-dalport-par-le-biais-dun-depistage-durine-universel-de-3-ans","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/detection-du-syndrome-dalport-par-le-biais-dun-depistage-durine-universel-de-3-ans\/","title":{"rendered":"D\u00e9tection du syndrome d’Alport par le biais d’un d\u00e9pistage d’urine universel de 3 ans"},"content":{"rendered":"
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Le premier diagnostic le plus courant du syndrome d’Alport au Japon est lors du d\u00e9pistage d’urine universel de 3 ans. Chez 60% de ces enfants, la maladie avait d\u00e9j\u00e0 progress\u00e9 suffisamment loin pour se qualifier pour le traitement. Par cons\u00e9quent, l’analyse d’urine universelle de l’\u00e2ge pr\u00e9coce peut \u00eatre un moyen appropri\u00e9 pour de meilleurs pronostics et des co\u00fbts r\u00e9duits des soins m\u00e9dicaux.<\/p>\n

Le syndrome d’Alport est une maladie g\u00e9n\u00e9tique qui affecte environ une personne sur 5 000. Les patients ne peuvent pas produire un certain type de collag\u00e8ne qui entra\u00eene une insuffisance r\u00e9nale et peut \u00e9galement entra\u00eener une perte auditive et des changements dans l’\u0153il. Il existe des m\u00e9dicaments qui retardent l’apparition d’une insuffisance r\u00e9nale, apr\u00e8s quoi les patients ont besoin d’une transplantation r\u00e9nale ou d’une dialyse.<\/p>\n

Cependant, bien que cela fonctionne mieux, plus t\u00f4t, la condition est identifi\u00e9e, de nombreuses personnes ne prennent conscience de la condition qu’une fois que le dysfonctionnement r\u00e9nal s’est d\u00e9j\u00e0 install\u00e9.<\/p>\n

\u00ab\u00a0Le Japon effectue un d\u00e9pistage de l’analyse d’urine universelle \u00e0 l’\u00e2ge de 3 ans, mais aucune \u00e9tude \u00e0 grande \u00e9chelle n’a \u00e9t\u00e9 men\u00e9e pour \u00e9valuer son efficacit\u00e9 dans l’identification du syndrome d’Alport chez les enfants\u00a0\u00bb, explique le p\u00e9diatre de l’Universit\u00e9 de Kobe Ishimori Shingo. Lui et son \u00e9quipe se sont ainsi tourn\u00e9s vers des patients h\u00f4pitaux universitaires de Kobe \u00e2g\u00e9s de 18 ans et moins et diagnostiqu\u00e9 avec le syndrome d’Alport pour d\u00e9couvrir comment ils ont \u00e9t\u00e9 diagnostiqu\u00e9s pour la premi\u00e8re fois avec l’\u00e9tat.<\/p>\n

Dans le journal Rapports internationaux r\u00e9naux<\/i>ils pr\u00e9sentent leurs r\u00e9sultats. Ils ont constat\u00e9 que plus de 30% des patients, soit 113 des 356 patients, \u00e9taient r\u00e9f\u00e9r\u00e9s \u00e0 l’h\u00f4pital pour tester le syndrome d’Alport en raison des r\u00e9sultats du d\u00e9pistage de l’urine de 3 ans, ce qui \u00e9tait la raison la plus courante de r\u00e9f\u00e9rence. De plus, 60% de ces personnes ont d\u00e9j\u00e0 rempli les conditions de traitement.<\/p>\n

Ishimori dit: \u00ab\u00a0Notre \u00e9tude a r\u00e9v\u00e9l\u00e9 qu’une proportion remarquablement \u00e9lev\u00e9e d’enfants de 3 ans atteints du syndrome d’Alport n\u00e9cessitait d\u00e9j\u00e0 une intervention th\u00e9rapeutique m\u00eame s’ils \u00e9taient encore asymptomatiques. Par cons\u00e9quent, l’introduction d’un syst\u00e8me de test d’urine peut permettre une intervention avant le d\u00e9but de la dysfonction r\u00e9nale.\u00a0\u00bb<\/p>\n

L’\u00e9quipe de l’Universit\u00e9 de Kobe prend soin de noter que bien que l’analyse d’urine universelle soit le d\u00e9clencheur le plus courant de d\u00e9tection et est donc prometteur, cela ne dit pas \u00e0 quel point l’approche est efficace pour identifier les personnes ayant la condition de l’ensemble de la population.<\/p>\n

L’\u00e9quipe estime que le nombre d’enfants japonais qui ont subi un d\u00e9pistage au cours de la p\u00e9riode qui les rendrait \u00e9ligibles \u00e0 leur \u00e9tude \u00e9tait d’environ 23 millions, et on ne sait actuellement quelle fraction de celles-ci a \u00e9t\u00e9 correctement diagnostiqu\u00e9e avec la condition.<\/p>\n

\u00ab\u00a0Les enqu\u00eates futures devraient \u00e9valuer le rendement diagnostique de l’approche actuelle. Mais nous savons maintenant que la mise en \u0153uvre d’un syst\u00e8me de d\u00e9pistage qui facilite la d\u00e9tection pr\u00e9coce et permet une intervention pr\u00e9coce pourrait offrir des avantages consid\u00e9rables\u00a0\u00bb, explique Ishimori.<\/p>\n

Ces avantages s’\u00e9tendent non seulement \u00e0 une meilleure qualit\u00e9 de vie pour les patients touch\u00e9s, mais aussi \u00e0 l’\u00e9conomie des soins de sant\u00e9 en r\u00e9duisant la charge de la gestion des insuffisances r\u00e9nales terminales, comme par dialyse ou transplantation r\u00e9nale.<\/p>\n

Le chercheur de l’Universit\u00e9 de Kobe conclut: \u00ab\u00a0Comme de nombreux pays n’ont pas de d\u00e9pistage de l’analyse d’urine universelle \u00e0 l’\u00e2ge de 3 ans, et m\u00eame pas toutes les municipalit\u00e9s au Japon effectuent les tests pertinents pour le syndrome d’Alport, nos r\u00e9sultats devraient favoriser l’adoption plus large des mesures conduisant \u00e0 une d\u00e9tection ant\u00e9rieure et un traitement ant\u00e9rieur.\u00a0\u00bb<\/p>\n

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Le premier diagnostic le plus courant du syndrome d’Alport au Japon est lors du d\u00e9pistage<\/p>\n","protected":false},"author":1,"featured_media":10365,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[38,6522,6996,1002,2366,528,1932,540,283,6300],"class_list":["post-10364","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-ans","tag-biais","tag-dalport","tag-depistage","tag-detection","tag-dun","tag-durine","tag-par","tag-syndrome","tag-universel","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nD\u00e9tection du syndrome d'Alport par le biais d'un d\u00e9pistage d'urine universel de 3 ans - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/detection-du-syndrome-dalport-par-le-biais-dun-depistage-durine-universel-de-3-ans\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"D\u00e9tection du syndrome d'Alport par le biais d'un d\u00e9pistage d'urine universel de 3 ans - 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