{"id":10349,"date":"2025-10-07T04:27:37","date_gmt":"2025-10-07T02:27:37","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/des-echantillons-de-tissus-rares-revelent-ou-le-vih-se-cache-dans-differentes-parties-du-corps\/"},"modified":"2025-10-07T04:27:38","modified_gmt":"2025-10-07T02:27:38","slug":"des-echantillons-de-tissus-rares-revelent-ou-le-vih-se-cache-dans-differentes-parties-du-corps","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/des-echantillons-de-tissus-rares-revelent-ou-le-vih-se-cache-dans-differentes-parties-du-corps\/","title":{"rendered":"Des \u00e9chantillons de tissus rares r\u00e9v\u00e8lent o\u00f9 le VIH se cache dans diff\u00e9rentes parties du corps"},"content":{"rendered":"
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Des chercheurs de Western et de l’Universit\u00e9 de Calgary ont d\u00e9couvert comment le VIH se cache dans diff\u00e9rentes parties du corps en s’inclinant dans l’ADN des cellules de mani\u00e8re sp\u00e9cifique au tissu, ce qui explique de nouvelles perspectives sur les raisons pour lesquelles le virus est si difficile \u00e0 \u00e9liminer et \u00e0 gu\u00e9rir, m\u00eame des d\u00e9cennies apr\u00e8s l’infection et le traitement.<\/p>\n

L’\u00e9tude, dirig\u00e9e par Stephen Barr de Western et Guido van Marle d’Ucalgary, r\u00e9v\u00e8le que le VIH se masque dans l’ADN des cellules infect\u00e9es en utilisant des mod\u00e8les d’ADN uniques dans le cerveau, le sang et certaines parties du tube digestif. Par exemple, dans le cerveau, le virus \u00e9vite les g\u00e8nes et les cache dans des parties moins actives de l’ADN. Les r\u00e9sultats sont publi\u00e9s dans M\u00e9decine des communications<\/i>.<\/p>\n

\u00ab\u00a0Nous avons constat\u00e9 que le VIH ne s’int\u00e8gre pas au hasard. Au lieu de cela, il suit des mod\u00e8les uniques dans diff\u00e9rents tissus, peut-\u00eatre fa\u00e7onn\u00e9s par l’environnement local et les r\u00e9ponses immunitaires\u00a0\u00bb, a d\u00e9clar\u00e9 Barr, professeur de microbiologie et d’immunologie \u00e0 la Schulich School of Medicine & Dentistry de Western’s Schulich. \u00ab\u00a0Cela aide \u00e0 expliquer comment le VIH parvient \u00e0 persister dans le corps pendant des d\u00e9cennies et pourquoi certains tissus peuvent agir comme des r\u00e9servoirs d’infection.\u00a0\u00bb<\/p>\n

Pour l’\u00e9tude, Barr, Van Marle et leurs collaborateurs de la Southern Alberta VIH Clinic et de l’Universit\u00e9 de l’Alberta ont utilis\u00e9 des \u00e9chantillons de tissus rares de personnes vivant avec le virus pendant les premi\u00e8res ann\u00e9es de la pand\u00e9mie du VIH \/ sida (vers 1993), avant le traitement moderne. Cela a donn\u00e9 aux chercheurs une occasion unique de voir comment le virus s’est comport\u00e9 dans son \u00e9tat naturel sur diff\u00e9rents organes, tous au sein des m\u00eames individus.<\/p>\n

\u00ab\u00a0Notre \u00e9tude est un puissant exemple de la fa\u00e7on dont nous pouvons apprendre des \u00e9chantillons historiques pour mieux comprendre un virus qui continue d’affecter des dizaines de millions de personnes dans le monde\u00a0\u00bb, a d\u00e9clar\u00e9 Barr, professeur de m\u00e9decine et de dentisterie de Schulich de microbiologie et d’immunologie.<\/p>\n

L’\u00e9quipe de recherche reconna\u00eet les personnes qui se sont port\u00e9es volontaires pour participer \u00e0 des \u00e9tudes au cours des premiers jours incertains de la pand\u00e9mie du VIH \/ sida.<\/p>\n

\u00ab\u00a0Leur volont\u00e9 de contribuer des \u00e9chantillons, \u00e0 un moment de stigmatisation, de peur et avec des options de traitement limit\u00e9es, \u00e9tait un acte de bravoure, de pr\u00e9voyance et de g\u00e9n\u00e9rosit\u00e9 qui continue de faire progresser la compr\u00e9hension scientifique du VIH et de sauver des vies aujourd’hui\u00a0\u00bb, a d\u00e9clar\u00e9 Van Marle, Microbiology, Immunology and Infectious Diseases Professeur du Cumming School of Medicine d’Ucalgary.<\/p>\n

Nouvelle attaque cibl\u00e9e<\/h2>\n

Pour cette nouvelle approche canadienne pour comprendre le VIH, les chercheurs ont \u00e9tudi\u00e9 les \u00e9chantillons historiques pr\u00e9lev\u00e9s dans l’\u0153sophage, le sang, l’estomac, l’intestin gr\u00eale et le c\u00f4lon des individus atteints de tissu c\u00e9r\u00e9bral in\u00e9gal\u00e9 d’autres individus. Ils ont \u00e9valu\u00e9 la fr\u00e9quence \u00e0 laquelle le virus s’est int\u00e9gr\u00e9 \u00e0 des r\u00e9gions sp\u00e9cifiques du g\u00e9nome et a compar\u00e9 ces mod\u00e8les dans divers tissus de diff\u00e9rents individus.<\/p>\n

\u00ab\u00a0Savoir o\u00f9 le virus se cache dans nos g\u00e9nomes nous aidera \u00e0 identifier les moyens de cibler ces cellules et ces tissus avec des approches th\u00e9rapeutiques cibl\u00e9es, soit en \u00e9liminant ces cellules ou en` `silenc\u00e9 \u00a0\u00bb le virus\u00a0\u00bb, a d\u00e9clar\u00e9 Van Marle.<\/p>\n

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Des chercheurs de Western et de l’Universit\u00e9 de Calgary ont d\u00e9couvert comment le VIH se<\/p>\n","protected":false},"author":1,"featured_media":10350,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[2454,2721,44,16,319,1292,805,5083,1052,149,4577,1624],"class_list":["post-10349","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-cache","tag-corps","tag-dans","tag-des","tag-differentes","tag-echantillons","tag-ou","tag-parties","tag-rares","tag-revelent","tag-tissus","tag-vih","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nDes \u00e9chantillons de tissus rares r\u00e9v\u00e8lent o\u00f9 le VIH se cache dans diff\u00e9rentes parties du corps - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/des-echantillons-de-tissus-rares-revelent-ou-le-vih-se-cache-dans-differentes-parties-du-corps\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Des \u00e9chantillons de tissus rares r\u00e9v\u00e8lent o\u00f9 le VIH se cache dans diff\u00e9rentes parties du corps - 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