{"id":10343,"date":"2025-10-07T01:44:35","date_gmt":"2025-10-06T23:44:35","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/les-etudes-de-la-colonne-vertebrale-du-poisson-zebre-revelent-de-nouveaux-indices-sur-la-detection-precoce-de-la-scoliose\/"},"modified":"2025-10-07T01:44:42","modified_gmt":"2025-10-06T23:44:42","slug":"les-etudes-de-la-colonne-vertebrale-du-poisson-zebre-revelent-de-nouveaux-indices-sur-la-detection-precoce-de-la-scoliose","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/les-etudes-de-la-colonne-vertebrale-du-poisson-zebre-revelent-de-nouveaux-indices-sur-la-detection-precoce-de-la-scoliose\/","title":{"rendered":"Les \u00e9tudes de la colonne vert\u00e9brale du poisson z\u00e8bre r\u00e9v\u00e8lent de nouveaux indices sur la d\u00e9tection pr\u00e9coce de la scoliose"},"content":{"rendered":"
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Le Dr Brian Ciruna n’avait aucune intention d’\u00e9tudier la scoliose, une condition qui provoque une courbure non naturelle de la colonne vert\u00e9brale. Cependant, la d\u00e9couverte inattendue il y a environ dix ans que le poisson z\u00e8bre d\u00e9veloppe \u00e9galement des \u00e9pines incurv\u00e9es lui a laiss\u00e9 se demander ce qui provoquait la colonne vert\u00e9brale et s’il y avait un lien avec la forme humaine de la maladie. Il s’av\u00e8re que ce petit poisson en vrac a beaucoup \u00e0 dire aux chercheurs d’une condition qui affecte 3% \u00e0 4% des enfants et des jeunes adolescents au Canada.<\/p>\n

Malgr\u00e9 sa pr\u00e9valence, nous savons tr\u00e8s peu les causes sous-jacentes de la scoliose chez l’homme, explique Ciruna, scientifique principal et chef du programme de biologie des cellules du d\u00e9veloppement et des souches de l’h\u00f4pital pour les enfants malades (malades) \u00e0 Toronto et professeur au D\u00e9partement de g\u00e9n\u00e9tique mol\u00e9culaire de l’Universit\u00e9 de Toronto. Il s’av\u00e8re que le poisson z\u00e8bre, il s’av\u00e8re que les squeries humaines, ce qui en fait un excellent mod\u00e8le pour cette recherche.<\/p>\n

Dans leurs derni\u00e8res recherches, publi\u00e9es dans Communications de la nature<\/i>Ciruna et son \u00e9quipe ont utilis\u00e9 des techniques d’imagerie sp\u00e9ciales \u00e0 la source de lumi\u00e8re canadienne (CLS) \u00e0 l’Universit\u00e9 de la Saskatchewan pour cr\u00e9er une carte 3D haute r\u00e9solution des \u00e9pines de poisson incurv\u00e9es, et ont not\u00e9 qu’elles agissent beaucoup comme des \u00e9pines humaines \u00e0 mesure que la scoliose s’aggrave.<\/p>\n

Leur imagerie a montr\u00e9 des d\u00e9formations et une raideur accrue dans les structures vert\u00e9brales, qui sont \u00e9galement observ\u00e9es chez les patients humains, explique Ciruna. \u00ab\u00a0C’est pronostique. Sur la base de la raideur, nous avons pu pr\u00e9dire quels poissons d\u00e9velopperaient une scoliose.\u00a0\u00bb Cette constatation est importante, car il n’y a actuellement pas de biomarqueurs g\u00e9n\u00e9tiques pour sugg\u00e9rer quels enfants d\u00e9veloppent une forme grave de la maladie.<\/p>\n

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\n https:\/\/www.youtube.com\/watch?v=g4jeuufhbmg<\/a>\n <\/p>\n<\/figure>\n

\u00c0 l’heure actuelle, dit Ciruna, \u00ab\u00a0les enfants et les familles doivent attendre\u00a0\u00bb pour voir comment la courbure progresse, puis affronter le contreventement ou la chirurgie invasive comme traitement. Un biomarqueur comme une raideur pourrait conduire \u00e0 une intervention pr\u00e9coce, et une \u00e9tude clinique en cours chez SickKids tente de d\u00e9terminer si la th\u00e9orie est valide, explique Ciruna.<\/p>\n

Des recherches ant\u00e9rieures de l’\u00e9quipe de SickKids avaient montr\u00e9 que le stress inflammatoire et oxydatif – un d\u00e9s\u00e9quilibre entre les radicaux libres et les antioxydants dans le corps – semble entra\u00eener la courbure vert\u00e9brale chez le poisson z\u00e8bre.<\/p>\n

Il reste de nombreuses questions \u00e0 r\u00e9pondre, explique Ciruna, notamment si les facteurs environnementaux tels que l’alimentation, l’exercice, l’infection et le biome intestinal peuvent cr\u00e9er du stress oxydatif et, finalement, la scoliose, et l’efficacit\u00e9 possible de la th\u00e9rapie antioxydante chez l’homme. \u00ab\u00a0Mais ce sont des mod\u00e8les pr\u00e9cliniques avec lesquels nous avons affaire en ce moment.\u00a0\u00bb<\/p>\n

Ciruna et ses coll\u00e8gues le consid\u00e8rent comme un luxe d’avoir acc\u00e8s \u00e0 la technologie CLS pour faire avancer leur \u00e9tude d’une condition qui \u00ab\u00a0est si courante qu’elle est n\u00e9glig\u00e9\u00a0\u00bb.<\/p>\n

Ciruna dit: \u00ab\u00a0Le d\u00e9veloppement \u00e9ventuel d’un traitement non invasif pour la cause sous-jacente de la scoliose pourrait \u00eatre transformateur.\u00a0\u00bb<\/p>\n

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Le Dr Brian Ciruna n’avait aucune intention d’\u00e9tudier la scoliose, une condition qui provoque une<\/p>\n","protected":false},"author":1,"featured_media":10344,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[1662,2366,1041,4001,49,992,1724,2555,149,6986,112,1663,1725],"class_list":["post-10343","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-colonne","tag-detection","tag-etudes","tag-indices","tag-les","tag-nouveaux","tag-poisson","tag-precoce","tag-revelent","tag-scoliose","tag-sur","tag-vertebrale","tag-zebre","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nLes \u00e9tudes de la colonne vert\u00e9brale du poisson z\u00e8bre r\u00e9v\u00e8lent de nouveaux indices sur la d\u00e9tection pr\u00e9coce de la scoliose - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/les-etudes-de-la-colonne-vertebrale-du-poisson-zebre-revelent-de-nouveaux-indices-sur-la-detection-precoce-de-la-scoliose\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Les \u00e9tudes de la colonne vert\u00e9brale du poisson z\u00e8bre r\u00e9v\u00e8lent de nouveaux indices sur la d\u00e9tection pr\u00e9coce de la scoliose - 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